何伟奇
苏州大学剑桥-苏大基因组资源中心教授
中国细胞学会生物节律分会委员会委员
简介
何伟奇,博士,剑桥-苏大基因组资源中心教授、课题组长,苏州大学“仲英青年学者”。主要从事肠道上皮稳态调控研究。主持国家自然科学基金2项,江苏省自然基金1项,Crohn's & Colitis Foundation基金1项。担任Gastroenterology,CMGH,J Biol Chem,Cell Death Dis等知名期刊审稿人。
教育经历
2001 – 2005,南京大学,生命科学学院,理学学士
2005 – 2010,南京大学,模式动物研究所,理学博士
工作经历
2010 – 2012,南京大学,医学院基础医学系,博士后
2012 – 2015,芝加哥大学,医学院病理系,博士后
2015 – 至今,苏州大学,剑桥-苏大基因组资源中心,教授
主要研究领域与方向
肠黏膜屏障紊乱及炎症性肠病的发生机制
肠道和生物节律之间的相互作用机制
炎症因子调控小肠干细胞增殖和分化的机制
著作
Graham WV*, He WQ*, Marchiando AM, Zha JM, Gurminder S, Li HS, Biswas A, Jiang ZH, Choi W, Zuccola H, Wang YT, Griffith J, Wu J, Rosenberg H, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular diversion blocks specific MLCK functions to restore mucosal barriers. Nat Med. 2019. 25(4):690-700.
Juan-Min Zha; Hua-Shan Li; Qian Lin; Wei-Ting Kuo; Zhi-Hui Jiang; Pei-Yun Tsai; Ning Ding; Jia Wu; Shao-Fang Xu; Yi-Tang Wang; Jian Pan; Xiu-Min Zhou; Kai Chen; Min Tao; Matthew A. Odenwald; Atsushi Tamura; Sachiko Tsukita; Jerrold R. Turner; Wei-Qi He. Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling. Cell Mol Gastroenterol Hepatol, 2019. 7(2): p. 255-274. 
Li, B. R., Wu, J., Li, H. S., Jiang, Z. H., Zhou, X. M., Xu, C. H., Ding, N., Zha, J. M., He, W. Q. In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability. J. Vis. Exp. 2018. 140: e57032.
Tsai P.Y., Zhang B., He W.Q., Zha J.M., Odenwald M.A., Singh G., Tamura A., Shen L., Sailer A., Yeruva S., Kuo W.T., Fu Y.X., Tsukita S., and Turner J.R., IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe, 2017. 21(6): p. 671-681e4.
Li H.S., Lin Q., Wu J., Jiang Z.H., Zhao J.B., Pan J., He W.Q.#, and Zha J.M.#, Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development. Biomed Pharmacother, 2017. 92: p. 810-818.
Zhang C.H., Wang P., Liu D.H., Chen C.P., Zhao W., Chen X., Chen C., He W.Q., Qiao Y.N., Tao T., Sun J., Peng Y.J., Lu P., Zheng K., Craige S.M., Lifshitz L.M., Keaney J.F., Jr., Fogarty K.E., ZhuGe R., and Zhu M.S., The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun, 2016. 7: p.11358.
Zha J.M., Li H.S., Wang Y.T., Lin Q., Tao M., and He W.Q., Characterization of isoform expression and subcellular distribution of MYPT1 in intestinal epithelial cells. Gene, 2016. 588(1): p. 1-6.
Gao N., Chang A.N., He W., Chen C.P., Qiao Y.N., Zhu M., Kamm K.E., and Stull J.T., Physiological signalling to myosin phosphatase targeting subunit-1 phosphorylation in ileal smooth muscle. J Physiol, 2016.594(12):p. 3209-25.
Chen C.P., Chen X.,Qiao Y.N., Wang P., He W.Q., Zhang C.H., Zhao W., Gao Y.Q., Chen C., Tao T., Sun J., Wang Y., Gao N., Kamm K.E., Stull J.T., and Zhu M.S., In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction. J Physiol, 2015. 593(3): p.681-700.
Tsai M.H., Chang A.N., Huang J., He W., Sweeney H.L., Zhu M., Kamm K.E., and Stull J.T., Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle. J Physiol, 2014. 592(14): p. 3031-51.
Qiao Y.N.*, He W.Q.*, Chen C.P., Zhang C.H., Zhao W., Wang P., Zhang L., Wu Y.Z., Yang X., Peng Y.J., Gao J.M., Kamm K.E., Stull J.T., and Zhu M.S., Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. J Biol Chem, 2014. 289(32):p. 22512-23.
Chen C., Tao T., Wen C., He W.Q., Qiao Y.N., Gao Y.Q., Chen X., Wang P., Chen C.P., Zhao W., Chen H.Q., Ye A.P., Peng Y.J., and Zhu M.S., Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism. J Biol Chem, 2014. 289(41): p.28478-88.
He W.Q., Qiao Y.N., Peng Y.J., Zha J.M., Zhang C.H., Chen C., Chen C.P., Wang P.,Yang X., Li C.J., Kamm K.E., Stull J.T., and Zhu M.S., Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1. Gastroenterology, 2013. 144(7):p. 1456-65, 1465 e1-5.
Gao N., Huang J., He W., Zhu M., Kamm K.E., and Stull J.T., Signaling through myosin light chain kinase in smooth muscles. J Biol Chem, 2013. 288(11): p.7596-605.
Yu Y., Lv N., Lu Z., Zheng Y.Y., Zhang W.C., Chen C., Peng Y.J., He W.Q., Meng F.Q., Zhu M.S., and Chen H.Q., Deletion of myosin light chain kinase in endothelial cells has a minor effect on the lipopolysaccharide-induced increase in microvascular endothelium permeability in mice. FEBS J, 2012. 279(8): p. 1485-94.
Zha J., Chen X., Li C., Zhu M., Ding G., and He W., One-step construction of lentiviral reporter using Red-mediated recombination. Mol Biotechnol, 2011. 49(3): p.278-82.
He W.Q., Qiao Y.N., Zhang C.H., Peng Y.J., Chen C., Wang P., Gao Y.Q., Chen C., Chen X., Tao T., Su X.H., Li C.J., Kamm K.E., Stull J.T., and Zhu M.S., Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension. Am J Physiol Heart Circ Physiol, 2011. 301(2): p.H584-91.
Wang L., Guo D.C., Cao J., Gong L., Kamm K.E., Regalado E., Li L., Shete S., He W.Q., Zhu M.S., Offermanns S., Gilchrist D., Elefteriades J.,Stull J.T., and Milewicz D.M., Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet, 2010. 87(5): p. 701-7.
Peng Y.J.*, He W.Q.*, Tang J., Tao T., Chen C., GaoY.Q., Zhang W.C., He X.Y., Dai Y.Y., Zhu N.C., Lv N., Zhang C.H., Qiao Y.N.,Zhao L.P., Gao X., and Zhu M.S., Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem, 2010. 285(32): p. 24834-44.
He W.Q., Peng Y.J., Zhang W.C., Lv N., Tang J., Chen C., Zhang C.H., Gao S., Chen H.Q., Zhi G., Feil R., Kamm K.E., Stull J.T., Gao X., and Zhu M.S., Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology, 2008. 135(2): p. 610-20.
Yang C.X., Chen H.Q., Chen C., Yu W.P., Zhang W.C., Peng Y.J., He W.Q., Wei D.M., Gao X., and Zhu M.S.,Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase. Cell Res, 2006. 16(4):p. 367-76.