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热心肠智库
专家文章 | 郝海平
2023
CA
Intracellular spatiotemporal metabolism in connection to target engagement
Adv Drug Deliv Rev, 10.1016/j.addr.2023.115024
CA
Chemoproteomic mapping of the glycolytic targetome in cancer cells
Nat Chem Biol, 10.1038/s41589-023-01355-w
CA
Polyunsaturated fatty acids drive neutrophil extracellular trap formation in nonalcoholic steatohepatitis
EUR J PHARMACOL, 10.1016/j.ejphar.2023.175618
CA
Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions
Cell Rep, 10.1016/j.celrep.2023.112011
2022
CA
Cooperation of structural motifs controls drug selectivity in cyclin-dependent kinases: an advanced theoretical analysis
BRIEF BIOINFORM, 10.1093/bib/bbac544
CA
Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors
J MED CHEM, 10.1021/acs.jmedchem.2c01452
CA
Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect
PharmSciTech, 10.1208/s12249-022-02402-w
CA
Comprehensive metabolomic profiling of nutrients in fish and shrimp
FOOD CHEM, 10.1016/j.foodchem.2022.135037
CA
Living Cell-Target Responsive Accessibility Profiling Reveals Silibinin Targeting ACSL4 for Combating Ferroptosis
ANAL CHEM, 10.1021/acs.analchem.2c03515
CA
Aberrant branched-chain amino acid accumulation along the microbiota-gut-brain axis: Crucial targets affecting the occurrence and treatment of ischaemic stroke
BR J PHARMACOL, 10.1111/bph.15965
点击查看热心肠日报解读
CA
Aberrant BCAA Accumulation along the Microbiota-Gut-Brain Axis:Crucial Targets Affecting the Occurrence and Treatment of Ischemic Stroke
BR J PHARMACOL, 10.1111/bph.15965
点击查看热心肠日报解读
CA
Determination of Molecule Category of Ligands Targeting the Ligand-Binding Pocket of Nuclear Receptors with Structural Elucidation and Machine Learning
J CHEM INF MODEL, 10.1021/acs.jcim.2c00851
CA
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
ACTA PHARM SIN B, 10.1016/j.apsb.2022.08.019
CA
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
ACTA PHARM SIN B, 10.1016/j.apsb.2022.08.019
CA
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
ACTA PHARM SIN B, 10.1016/j.apsb.2022.08.019
CA
Bile acid restrained T cell activation explains cholestasis aggravated hepatitis B virus infection
FASEB J, 10.1096/fj.202200332R
CA
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS
ACTA PHARM SIN B, 10.1016/j.apsb.2022.07.006
CA
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS
ACTA PHARM SIN B, 10.1016/j.apsb.2022.07.006
CA
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS
ACTA PHARM SIN B, 10.1016/j.apsb.2022.07.006
CA
Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
Nat Methods, 10.1038/s41592-022-01523-1