翟齐啸团队:饮食和菌群如何调节肠道黏蛋白糖基化?(综述)
创作:大力 审核:mildbreeze 2021年04月10日
  • 黏蛋白糖基化在调节肠道菌群、维持黏液屏障及免疫信号传导等方面起着重要作用;
  • 宿主免疫等因素调节黏蛋白糖基化,IBD、大肠癌等肠道疾病伴随着肠上皮特定糖基化改变;
  • 肠道微生物通过脂多糖、黏附素、糖苷酶、代谢产物(SCFAs、色氨酸代谢物)等调节黏蛋白糖基化;
  • 膳食成分(如脂肪、纤维、益生元、蛋白质和食品添加剂)会影响黏蛋白糖基化和黏膜稳态;
  • 未来或可为IBD、大肠癌等患者提供靶向黏蛋白糖基化的个性化饮食以辅助治疗。
主编推荐语
mildbreeze
江南大学翟齐啸团队近期在Carbohydrate Polymers发表综述,探讨了肠道的黏蛋白糖基化在肠道疾病中的作用,重点总结了影响宿主免疫、肠道菌群和饮食等因素对黏蛋白糖基化的影响,并对基于黏蛋白糖基化的个体化干预进行了展望,推荐专业人士参考。
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The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation

饮食和肠道菌群对肠道黏蛋白糖基化的调节作用

10.1016/j.carbpol.2021.117651

2021-01-19, Review

Abstract & Authors:展开

Abstract:收起
Intestinal mucins glycosylation is regulated by host cues and environmental signals from the microbiome and diets. However, the mechanisms responsible for the dialogue between these three factors and mucin glycosylation in the digestive environment of the host are not well understood. In this review, the dynamic alterations of mucin glycosylation induced by immune responses to gut diseases are summarized. The various types of interactions between mucin glycans and gut microbes, including adhesins, glycosidases, metabolic products and surface components, are discussed. The mechanisms that determine how dietary components (fat, fiber, prebiotics, protein, and food additives) affect intestinal mucin glycosylation and maintain mucosal homeostasis are identified. A potential framework for individualized dietary recommendations is proposed for the prevention of abnormal mucin glycosylation driven by immune dysregulation, gut microbiome alterations and other factors. This review may provide a basis for future research on glycosylation-inspired therapies for gut diseases.

First Authors:
Dingwu Qu

Correspondence Authors:
Qixiao Zhai

All Authors:
Dingwu Qu,Gang Wang,Leilei Yu,Fengwei Tian,Wei Chen,Qixiao Zhai

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