湘雅医院:患有单一心血管代谢疾病的人,应少喝两类甜饮料
创作:芥末 审核:mildbreeze 2022年08月21日
  • 纳入37994名有一种心血管代谢病的患者,中位随访9.1年,探索含糖饮料(SSB)、人工甜饮料(ASB)和纯果汁/蔬菜汁的摄入与发展为心血管代谢共病(CMM)风险的关系;
  • 每天摄入>1份SSB或ASB显著增加CMM发生风险(HR分别为1.19、1.15);
  • 纯果汁/蔬果汁的摄入量与CMM风险呈负相关(每日摄入量0-1份的HR为0.90,>1份时相关性减弱);
  • 高血压患者摄入SSB与CMM风险升高相关,高血压及心血管疾病患者摄入纯果汁/蔬果汁与CMM风险降低相关。
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mildbreeze
饮料与单一种类的心血管代谢疾病(CMD,如糖尿病、高血压、冠心病和中风)间的关系已被充分研究,但不同类型的饮料在从患有一种CMD发展为同时患多种CMD的心血管代谢性共病(CMM)过程中的作用仍不清楚。中南大学湘雅医院的张国刚、Xunjie Cheng与团队在BMC Medicine发表研究,针对这一问题进行了探索。该研究通过分析英国生物样本库的基线和随访数据,表明CMD患者或应限制含糖饮料和使用非营养性甜味剂的人工甜饮料的摄入。
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BMC Medicine [IF:11.15]

Associations between consumption of three types of beverages and risk of cardiometabolic multimorbidity in UK Biobank participants: a prospective cohort study

英国生物样本库参与者的三种饮料摄入与心血管代谢共病风险之间的关系:一项前瞻性队列研究

10.1186/s12916-022-02456-4

2022-08-18, Article

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Background: Although the association between beverages and a single cardiometabolic disease has been well studied, their role in disease progression from the single cardiometabolic disease state to cardiometabolic multimorbidity (CMM) state remains unclear. This study examined the associations between three types of beverages: sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and pure fruit/vegetable juices, and the incidence of CMM in patients with a single cardiometabolic disease.
Methods: Our analysis included 37,994 participants from the UK Biobank who completed at least one dietary questionnaire and were diagnosed with only one cardiometabolic disease at the time of recruitment. Competing risk models were used to examine the association between the three types of beverages and incidence of CMM. We conducted analysis both in patients with any single cardiometabolic disease and in patients with specific cardiometabolic disease.
Results: During a median follow-up of 9.1 years (interquartile range [IQR] 9.0–9.8), a total of 6399 participants developed CMM. The consumption of SSBs and ASBs (>1 serving per day) was associated with a higher risk of CMM (SSBs: hazard ratio [HR] 1.19, 95% confidence interval [95% CI] 1.08–1.31; ASBs: HR 1.15, 95% CI 1.04–1.27). Intake of pure fruit/vegetable juices was inversely associated with the incidence of CMM (0–1 serving per day: HR 0.90, 95% CI 0.85–0.94; >1 serving per day: HR 0.90, 95% CI 0.81–0.99). However, the association of the high-level consumption of pure fruit/vegetable juices (>1 serving per day) was not statistically significant after correcting for multiple testing. In the analysis of patients with specific cardiometabolic diseases, positive associations were observed in patients with hypertension for SSBs consumption, while inverse associations persisted in patients with cardiovascular disease (coronary heart disease or stroke) and in hypertensive patients for pure fruit/vegetable juice consumption.
Conclusions: Consuming >1 serving of SSBs and ASBs per day was associated with a higher risk of CMM in patients with a single cardiometabolic disease. In contrast, intake of pure fruit/vegetable juices was inversely associated with the risk of CMM. Our findings highlight the need to limit the use of SSBs and ASBs in patients with a single cardiometabolic disease.

First Authors:
Yi Luo

Correspondence Authors:
Xunjie Cheng,Guogang Zhang

All Authors:
Yi Luo,Lingfang He,Tianqi Ma,Jinchen Li,Yongping Bai,Xunjie Cheng,Guogang Zhang

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