• 研究表明幽门螺旋杆菌感染与胰岛素抵抗相关,但背后的机制尚未明确;
  • 给幽门螺旋杆菌感染的小鼠模型喂食不同结构组成的饮食;
  • 幽门螺旋杆菌感染在早期显著恶化了高脂饮食引起的代谢紊乱,恶化程度接近于长期食用高脂饮食的效应;
  • 幽门螺旋杆菌感染及高脂饮食造成的肠道菌群动态变化一致。
蓝灿辉 | 热心肠先生
幽门螺旋杆菌感染在早期显著恶化了高脂饮食引起的代谢紊乱,恶化程度接近于长期食用高脂饮食的效应,幽门螺旋杆菌和肠道菌群的互作如何影响宿主的代谢,来自南昌大学的团队(主要成员在Hi Microbes群)的这篇文章做了初步探讨,值得一看。
EBioMedicine [IF:5.736]

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice



2016-09-12, Article

Abstract & Authors:展开

BACKGROUND: Emerging evidence suggests that Helicobacter pylori infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and H. pylori-associated IR.
METHODS: Using H. pylori-infected mice model fed different diet structures, we demonstrated that H. pylori infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD.
RESULTS: Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by H. pylori and HFD.
CONCLUSION: There may be an interaction among H. pylori, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control.

First Authors:
Cong He

Correspondence Authors:
Nonghua Lu

All Authors:
Cong He,Zhen Yang,Dandan Cheng,Chuan Xie,Yin Zhu,Zhongming Ge,Zhijun Luo,Nonghua Lu