早期牙周炎与克罗恩病的恶化相关
创作:aluba 审核:aluba 2021年11月06日
  • 纳入60名IBD患者及45名健康对照,进行12个月的随访;
  • IBD患者的肠道菌群与口腔菌群的相似度显著高于健康对照,提示IBD患者的口腔菌群的肠道定殖增加;
  • 早期牙周炎并不会进一步增加口腔细菌的肠道定殖;
  • 早期牙周炎也并未显著影响IBD患者的临床结局;
  • 在随访期间,患有早期牙周炎的克罗恩病患者的疾病活动指数增加,而无早期牙周炎的克罗恩病患者的疾病活动指数降低或不变。
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aluba
JCI insight上发表的一项前瞻性队列研究结果,对60名IBD患者及45名健康对照进行12个月随访,发现IBD患者的口腔菌群的肠道定殖显著增加,而早期牙周炎与克罗恩病患者的疾病活动指数增加相关。
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JCI insight [IF:8.315]

A potential pathogenic association between periodontal disease and Crohn's disease

牙周病与克罗恩病的潜在病理关联

10.1172/jci.insight.148543

2021-10-28, Article

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Oral conditions are relatively common in patients with inflammatory bowel disease (IBD). However, the contribution of oral maladies to gut inflammation remains unexplored. Here, we investigated the impact of periodontitis on disease phenotypes of IBD patients. In all, 60 IBD patients (42 with ulcerative colitis [UC] and 18 with Crohn's disease [CD]) and 45 non-IBD healthy controls (HCs) were recruited for this clinical investigation. The effects of incipient periodontitis on the oral and gut microbiome, IBD characteristics were examined. In addition, patients were prospectively monitored up to 12 months after enrollment. We found that in both UC and CD patients, the gut microbiome was significantly more similar to the oral microbiome than in HCs, suggesting that ectopic gut colonization by oral bacteria is increased in IBD patients. Incipient periodontitis did not further enhance gut colonization by oral bacteria. The presence of incipient periodontitis did not significantly affect the clinical outcomes of UC and CD patients. However, the short Crohn's disease activity index increased in CD patients with incipient periodontitis but declined or unchanged during the study period in patients without periodontitis. Thus, early periodontitis may associate with worse clinically symptoms in some patients with CD.

First Authors:
Jin Imai

Correspondence Authors:
Hitoshi Ichikawa,Nobuhiko Kamada

All Authors:
Jin Imai,Hitoshi Ichikawa,Sho Kitamoto,Jonathan L Golob,Motoki Kaneko,Junko Nagata,Miho Takahashi,Merritt G Gillilland,Rika Tanaka,Hiroko Nagao-Kitamoto,Atsushi Hayashi,Kohei Sugihara,Shrinivas Bishu,Shingo Tsuda,Hiroyuki Ito,Seiichiro Kojima,Kazunari Karakida,Masashi Matsushima,Takayoshi Suzuki,Katsuto Hozumi,Norihito Watanabe,William V Giannobile,Takayuki Shirai,Hidekazu Suzuki,Nobuhiko Kamada

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