Abstract & Authors:展开
Oral conditions are relatively common in patients with inflammatory bowel disease (IBD). However, the contribution of oral maladies to gut inflammation remains unexplored. Here, we investigated the impact of periodontitis on disease phenotypes of IBD patients. In all, 60 IBD patients (42 with ulcerative colitis [UC] and 18 with Crohn's disease [CD]) and 45 non-IBD healthy controls (HCs) were recruited for this clinical investigation. The effects of incipient periodontitis on the oral and gut microbiome, IBD characteristics were examined. In addition, patients were prospectively monitored up to 12 months after enrollment. We found that in both UC and CD patients, the gut microbiome was significantly more similar to the oral microbiome than in HCs, suggesting that ectopic gut colonization by oral bacteria is increased in IBD patients. Incipient periodontitis did not further enhance gut colonization by oral bacteria. The presence of incipient periodontitis did not significantly affect the clinical outcomes of UC and CD patients. However, the short Crohn's disease activity index increased in CD patients with incipient periodontitis but declined or unchanged during the study period in patients without periodontitis. Thus, early periodontitis may associate with worse clinically symptoms in some patients with CD.
Hitoshi Ichikawa,Nobuhiko Kamada
Jin Imai,Hitoshi Ichikawa,Sho Kitamoto,Jonathan L Golob,Motoki Kaneko,Junko Nagata,Miho Takahashi,Merritt G Gillilland,Rika Tanaka,Hiroko Nagao-Kitamoto,Atsushi Hayashi,Kohei Sugihara,Shrinivas Bishu,Shingo Tsuda,Hiroyuki Ito,Seiichiro Kojima,Kazunari Karakida,Masashi Matsushima,Takayoshi Suzuki,Katsuto Hozumi,Norihito Watanabe,William V Giannobile,Takayuki Shirai,Hidekazu Suzuki,Nobuhiko Kamada