杨宁+郑江霞:肉鸡胖不胖,肠道菌群贡献不小
创作:鱼儿 审核:mildbreeze 2019年02月27日
  • 使用206只肉鸡探究宿主遗传对肠道菌群组成的影响程度,并评估二者对脂肪沉积的贡献;
  • 菌群对特定肠道位置的环境具有高度适应性,不同肠道部位的菌群在多样性、组成和功能潜力方面都存在差异,而宿主遗传对菌群的影响有限;
  • 十二指肠和盲肠的菌群对脂肪沉积的贡献较大,盲肠中甲烷杆菌属和Mucispirillum schaedleri的丰度分别与脂肪沉积具有显著正和负相关性;
  • 改变肠道菌群或能控制肉鸡生产过程中的脂肪沉积。
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mildbreeze
中国农业大学杨宁团队与郑江霞团队合作的研究,近期在ISME Journal发表。该研究通过全基因组测序和16S rRNA基因测序,分析了肉鸡的遗传因素与肠道菌群,表明遗传因素对菌群的影响有限,而肉鸡的脂肪沉积受十二指肠和盲肠的菌群影响较大,尤其盲肠中两种细菌的丰度与腹部脂肪量显著相关。该研究对于研究宿主遗传对菌群的影响、二者对肥胖的贡献、肉鸡饲养,都很有参考价值。
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ISME Journal [IF:11.217]

The gut microbiota is largely independent of host genetics in regulating fat deposition in chickens

在调节鸡的脂肪沉积中,肠道菌群在很大程度上独立于宿主遗传

10.1038/s41396-019-0367-2

2019-02-06, Article

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The gut microbiota has an important role in animal health and performance, but its contribution is difficult to determine, in particular given the effects of host genetic factors. Here, whole-genome sequencing of the hosts and 16S rRNA gene sequencing of the microbiota were performed to separate the effects between host genetics and the microbiota in the duodenum, jejunum, ileum, caecum and faeces on fat deposition in 206 yellow broilers reared under identical conditions. Despite the notable spatial variation in the diversity, composition and potential function of the gut microbiota, host genetics exerted limited effects on the gut microbial community. The duodenal and caecal microbiota made greater contributions to fat deposition and could separately account for 24% and 21% of the variance in the abdominal fat mass after correcting for host genetic effects. We further identified two caecal microbial taxa, Methanobrevibacter and Mucispirillum schaedleri, which were significantly correlated with fat deposition. Chickens with a lower Methanobrevibacter abundance had significantly lower abdominal fat content than those with a higher abundance of Methanobrevibacter (35.51 vs. 55.59 g), and the body weights of these chickens did not notably differ. Chickens with a higher M. schaedleri abundance exhibited lower abdominal fat accumulation (39.88 vs. 55.06 g) and body weight (2.23 vs. 2.41 kg) than those with a lower abundance of this species. These findings may aid the development of strategies for altering the gut microbiota to control fat deposition during broiler production.

First Authors:
Chaoliang Wen

Correspondence Authors:
Jiangxia Zheng,Ning Yang

All Authors:
Chaoliang Wen,Wei Yan,Congjiao Sun,Congliang Ji,Qianqian Zhou,Dexiang Zhang,Jiangxia Zheng,Ning Yang

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