饮食与肠道菌群的抗生素耐药性有何关系?
创作:mildbreeze 审核:mildbreeze 05月11日
  • 纳入290名健康美国成人,研究饮食与肠道菌群抗生素耐药性的关系;
  • 氨基糖甙类抗生素的耐药基因(ARG)在肠道菌群中丰度最高、最普遍,氨基糖苷-O-磷酸转移酶(aph3-dprime)与膳食总热量和可溶性纤维摄入量呈负相关;
  • 菌群ARG水平低的人群,其膳食纤维摄入量较高、动物蛋白摄入量较低,伴随着菌群中有更多的专性厌氧菌(尤其是梭菌科成员);
  • 机器学习表明,较低的ARG水平与较高的食物种类多样性有关。
主编推荐语
mildbreeze
肠道菌群是抗生素耐药性的重要来源,饮食是塑造肠道菌群的一个有力方法,或能用于减少抗生素耐药性。然而,目前我们对饮食和菌群抗生素耐药性之间的关系仍所知甚少。mBio发表的这项研究发现,食用高纤维和低动物蛋白的多样化饮食的人,其肠道菌群有较少的抗生素耐药基因。这些数据表明,饮食可能是减少抗生素耐药负担的一个潜在方法。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
mBio [IF:7.786]

Association of Diet and Antimicrobial Resistance in Healthy U.S. Adults

美国健康成年人的饮食与抗菌素耐药性的关系

10.1128/mbio.00101-22

05-10, Article

Abstract & Authors:展开

Abstract:收起
Antimicrobial resistance (AMR) represents a significant source of morbidity and mortality worldwide, with expectations that AMR-associated consequences will continue to worsen throughout the coming decades. Since resistance to antibiotics is encoded in the microbiome, interventions aimed at altering the taxonomic composition of the gut might allow us to prophylactically engineer microbiomes that harbor fewer antibiotic resistant genes (ARGs). Diet is one method of intervention, and yet little is known about the association between diet and antimicrobial resistance. To address this knowledge gap, we examined diet using the food frequency questionnaire (FFQ; habitual diet) and 24-h dietary recalls (Automated Self-Administered 24-h [ASA24®] tool) coupled with an analysis of the microbiome using shotgun metagenome sequencing in 290 healthy adult participants of the United States Department of Agriculture (USDA) Nutritional Phenotyping Study. We found that aminoglycosides were the most abundant and prevalent mechanism of AMR in these healthy adults and that aminoglycoside-O-phosphotransferases (aph3-dprime) correlated negatively with total calories and soluble fiber intake. Individuals in the lowest quartile of ARGs (low-ARG) consumed significantly more fiber in their diets than medium- and high-ARG individuals, which was concomitant with increased abundances of obligate anaerobes, especially from the family Clostridiaceae, in their gut microbiota. Finally, we applied machine learning to examine 387 dietary, physiological, and lifestyle features for associations with antimicrobial resistance, finding that increased phylogenetic diversity of diet was associated with low-ARG individuals. These data suggest diet may be a potential method for reducing the burden of AMR.

First Authors:
Andrew Oliver

Correspondence Authors:
Danielle G Lemay

All Authors:
Andrew Oliver,Zhengyao Xue,Yirui T Villanueva,Blythe Durbin-Johnson,Zeynep Alkan,Diana H Taft,Jinxin Liu,Ian Korf,Kevin D Laugero,Charles B Stephensen,David A Mills,Mary E Kable,Danielle G Lemay

评论