肠道菌群或影响免疫治疗对肾癌患者的疗效
创作:aluba 审核:aluba 2020年08月24日
  • 收集31名接受纳武单抗或纳武单抗+伊匹单抗治疗的转移性肾细胞癌患者的粪便样本,其中58%的患者在治疗中获益;
  • 更高的粪便菌群丰度与从免疫检查点抑制剂治疗中获益显著相关;
  • 鉴定出多个细菌物种与临床获益与否显著相关,例如椭圆形拟杆菌等在非获益患者中显著富集,而青春双歧杆菌等在获益患者中显著富集;
  • 在临床获益患者中,Akk菌的相对丰度随着治疗进程而逐渐升高。
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aluba
临床前动物模型与一些早期临床数据显示,肠道菌群可能影响包括肾细胞癌在内的实体瘤患者对免疫治疗的应答。European Urology上发表的一项最新研究,对31名接受纳武单抗(PD-1单抗)或纳武单抗+伊匹单抗(CTLA-4单抗)治疗的转移性肾细胞癌患者进行分析,发现粪便菌群的多样性、特定细菌物种的丰度与患者对治疗的应答相关。另外,应答患者在治疗过程中,可观察到Akk菌的相对丰度逐渐增加。
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European Urology [IF:24.267]

Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti–PD-1 Immune Checkpoint Inhibitors

接受PD-1单抗治疗的转移性肾细胞癌患者的粪便菌群谱

10.1016/j.eururo.2020.07.011

2020-08-19, Article

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Preclinical models and early clinical data suggest an interplay between the gut microbiome and response to immunotherapy in solid tumors including metastatic renal cell carcinoma (mRCC). We sought to characterize the stool microbiome of mRCC patients receiving a checkpoint inhibitor (CPI) and to assess treatment-related changes in microbiome composition over the course of CPI therapy. Stool was collected from 31 patients before initiation of nivolumab (77%) or nivolumab plus ipilimumab (23%) therapy, of whom 58% experienced clinical benefit. Greater microbial diversity was associated with clinical benefit from CPI therapy ( p =  0.001), and multiple species were associated with clinical benefit or lack thereof. Temporal profiling of the microbiome indicated that the relative abundance of Akkermansia muciniphila increased in patients deriving clinical benefit from CPIs. This study substantiates results from previous CPI-related microbiome profiling studies in mRCC. Temporal changes in microbiome composition suggest potential utility in modulating the microbiome for more successful CPI outcomes.

First Authors:
Nicholas J Salgia,Paulo G Bergerot

Correspondence Authors:
Sarah K Highlander,Sumanta K Pal

All Authors:
Nicholas J Salgia,Paulo G Bergerot,Manuel Caitano Maia,Nazli Dizman,JoAnn Hsu,John D Gillece,Megan Folkerts,Lauren Reining,Jeffrey Trent,Sarah K Highlander,Sumanta K Pal

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