微生物引起癌症突变的多种方式(观点)
  • 菌群可通过多种方式引起宿主的基因突变,增加癌症风险;
  • 某些细菌可产生有基因毒性的colibactin、细胞致死膨胀毒素、活性氧、三氧化二氮等,直接诱导宿主DNA突变;
  • 或者通过引发特定免疫反应,释放次氯酸、次溴酸、激活诱导胞啶脱氨酶等,引起免疫细胞诱导的DNA损伤;
  • 菌群-饮食互作也可导致产生N-亚硝基化合物和乙醛等具有基因毒性的化合物;
  • 菌群还可能扰乱宿主的DNA损伤应答;
  • 基因突变特征分析可作为研究菌群对人类基因影响的工具。
主编推荐语
mildbreeze
基因突变是癌症发生的重要原因,近年的菌群研究表明,微生物可通过多种方式来促进宿主细胞产生基因突变。Trends in Cancer发表的一篇观点性文章,对微生物诱导宿主突变的多种潜在途径进行了总结,并指出分析癌症基因组的突变特征,是解析微生物促癌机制的重要方法。
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Trends in Cancer [IF:19.161]

Mutagenesis by Microbe: the Role of the Microbiota in Shaping the Cancer Genome

微生物引起的基因突变:菌群在塑造癌症基因组中的作用

10.1016/j.trecan.2020.01.019

2020-02-20, Article

Abstract & Authors:展开

Abstract:收起
Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumor microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the driver for somatic mutations. An understanding of microbiota-driven mutational mechanisms would contribute to a more complete understanding of the origins of the cancer genome. Here, we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures.

First Authors:
Maurice Barrett

Correspondence Authors:
Paul W O'Toole

All Authors:
Maurice Barrett,Collette K Hand,Fergus Shanahan,Thomas Murphy,Paul W O'Toole

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