国内团队:早发性大肠癌患者的肠道菌群特征
  • 纳入2个队列共1038人,包含早发性大肠癌(yCRC)、晚发性大肠癌(oCRC)和相应对照者,用16S测序分析粪便样本,并对200个样本做宏基因组测序;
  • 相较于同龄对照,yCRC菌群多样性降低,但高于oCRC;
  • Flavonifractor plautii是yCRC中的一个重要的富集菌种,而链球菌属在oCRC中增多;
  • yCRC有独特的细菌代谢功能特征,以DNA结合和RNA依赖的DNA生物合成过程为主;
  • 建立随机森林分类器模型,可基于微生物标志物将yCRC和oCRC与健康人进行区分。
主编推荐语
mildbreeze
早发性结直肠癌(yCRC,<50岁)的发病率正在快速增加,且其侵袭性更强,但目前关于yCRC的肠道菌群及其诊断价值尚缺乏深入研究。Nature Communications最新发表了复旦大学附属肿瘤医院马延磊团队的研究,重点分析了yCRC的肠道菌群组成和功能改变,揭示了其与晚发性CRC(oCRC,≥50岁)的差异,并基于粪便菌群标志物开发了诊断模型,或能用于yCRC的检测。
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Dysbiosis of human gut microbiome in young-onset colorectal cancer

人类肠道微生物组的菌群失调在年轻发病的结直肠癌中的作用

10.1038/s41467-021-27112-y

2021-11-19, Article

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The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients. Through 16S rRNA gene sequencing, 728 samples are collected to identify microbial markers, and an independent cohort of 310 samples is used to validate the results. Furthermore, species-level and functional analysis are performed by metagenome sequencing using 200 samples. Gut microbial diversity is increased in yCRC. Flavonifractor plautii is an important bacterial species in yCRC, while genus Streptococcus contains the key phylotype in the old-onset colorectal cancer. Functional analysis reveals that yCRC has unique characteristics of bacterial metabolism characterized by the dominance of DNA binding and RNA-dependent DNA biosynthetic process. The random forest classifier model achieves a powerful classification potential. This study highlights the potential of the gut microbiota biomarkers as a promising non-invasive tool for the accurate detection and distinction of individuals with yCRC.

First Authors:
Yongzhi Yang,Lutao Du,Debing Shi,Cheng Kong,Jianqiang Liu,Guang Liu

Correspondence Authors:
Yanlei Ma

All Authors:
Yongzhi Yang,Lutao Du,Debing Shi,Cheng Kong,Jianqiang Liu,Guang Liu,Xinxiang Li,Yanlei Ma

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生物医学科研之家微信公众号

年轻人发病的结直肠癌中人类肠道微生物群的失调

2021-11-28

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