清华程功团队:宿主血清中的铁抑制蚊子的登革热病毒感染
创作:aluba 审核:aluba
  • 给埃及伊蚊喂食人血与登革热病毒感染的Vero细胞培养上清的混合物,埃及伊蚊的登革热病毒感染与人血清中的铁元素水平呈负相关;
  • 埃及伊蚊叮咬感染了登革热病毒的小鼠,叮咬了注射转铁蛋白的小鼠的埃及伊蚊的病毒荷载量降低,而叮咬了注射去铁胺的小鼠的埃及伊蚊的病毒感染增加;
  • 机制上,血清中的(而非与血红蛋白结合的)铁元素可被蚊子的铁代谢通路利用,促进蚊子肠道上皮的活性氧活性,从而抑制登革热病毒的感染。
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aluba
血液中的组分及代谢产物可调节蚊子对虫媒病毒的易感性。来自清华大学的程功团队在Nature Microbiology上发表的一项最新研究,发现宿主血清中的铁元素含量与蚊子的登革热病毒感染水平呈负相关,前者通过促进蚊子肠道上皮的活性氧活性,抑制登革热病毒的感染。
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Nature Microbiology [IF:17.745]

Host serum iron modulates dengue virus acquisition by mosquitoes

宿主血清中的铁调节蚊子的登革热病毒感染

10.1038/s41564-019-0555-x

2019-09-16, Article

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A blood meal is the primary route through which mosquitoes acquire an arbovirus infection. Blood components or their metabolites may regulate the susceptibility of mosquitoes to arboviruses. Here we report that serum iron in human blood influences dengue virus acquisition by mosquitoes. Dengue virus acquisition by Aedes aegypti was inversely correlated with the iron concentration in serum from human donors. In a mouse–mosquito acquisition model, iron supplementation reduced dengue virus prevalence and viral load, whereas neutralization of serum iron facilitated dengue virus infection in A. aegypti mosquitoes. Of note, mosquitoes feeding on iron-deficient (sideropenic) mice exhibited a higher prevalence of dengue virus. Reversal of the sideropenic status of hosts largely reduced dengue virus acquisition and infection by mosquitoes. Serum iron, rather than haem-bound iron, was utilized by the mosquito iron metabolism pathway to boost the activity of reactive oxygen species in the gut epithelium, subsequently inhibiting infection by dengue virus. On the basis of these results, a status of iron deficiency in the human population might contribute to the vectorial permissiveness to dengue virus, thereby facilitating its spread by mosquitoes.

First Authors:
Yibin Zhu

Correspondence Authors:
Gong Cheng

All Authors:
Yibin Zhu,Liangqin Tong,Kaixiao Nie,Itsanun Wiwatanaratanabutr,Peng Sun,Qingqing Li,Xi Yu,Pa Wu,Tianshi Wu,Chen Yu,Qiyong Liu,Zhongqi Bian,Penghua Wang,Gong Cheng

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