菌群组成或影响骨髓增生性肿瘤患者的炎症状态
创作:圆圈儿 审核:章台柳 05月12日
  • 分别收集25名MPN和非MPN患者的3份粪便样本进行宏基因组分析MPN患者肠道菌群组成;
  • MPN和非MPN患者的肠道菌群组成存在明显差异,个体化性质导致大部分差异,而其中1.7%的差异来自于疾病状态;
  • MPN患者肠道中考拉杆菌属丰度显著降低,该菌与降低炎症相关;
  • MPN患者血清中TNF-α及IFN-β诱导的IP10水平增加;
  • 关联性分析发现考拉杆菌属、副拟杆菌属与TNF-α间具有相关性;
  • 这些差异菌可能在MPN慢性炎症中起作用。
主编推荐语
章台柳
骨髓增生性肿瘤(MPN)是一种慢性血液系统恶性肿瘤,炎症在其发生、发展和症状学中起着关键作用。而菌群具有在癌症中调节炎症的能力。Microbiology spectrum近期发表的文章,对MPN和非MPN患者进行肠道菌群分析,发现两者之间的菌群存在显著差异,特定的菌属在PMN的慢性炎症中具有重要作用。
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Fecal Microbial Community Composition in Myeloproliferative Neoplasm Patients Is Associated with an Inflammatory State

骨髓增殖性肿瘤(MPN)患者的粪便菌群组成与炎症状态有关

10.1128/spectrum.00032-22

04-27, Review

Abstract & Authors:展开

Abstract:收起
The capacity of the human microbiome to modulate inflammation in the context of cancer is becoming increasingly clear. Myeloproliferative neoplasms (MPNs) are chronic hematologic malignancies in which inflammation plays a key role in disease initiation, progression, and symptomatology. To better understand the composition of the gut microbiome in patients with MPN, triplicate fecal samples were collected from 25 MPN patients and 25 non-MPN controls. Although most of the variance between the microbial community compositions could be attributed to the individual (permutational analysis of variance [PERMANOVA], R2 = 0.92, P = 0.001), 1.7% of the variance could be attributed to disease status (MPN versus non-MPN). When a more detailed analysis was performed, significantly fewer reads mapping to a species of Phascolarctobacterium, a microbe previously associated with reduced inflammation, were found in MPNs. Further, our data revealed an association between Parabacteroides and tumor necrosis factor alpha (TNF-α), an inflammatory cytokine elevated in MPNs. Taken together, our results indicate a significant difference in the microbiome of MPN patients compared to non-MPN controls, and we identify specific species which may have a role in the chronic inflammation central to this disease.

First Authors:
Andrew Oliver,Kenza El Alaoui

Correspondence Authors:
Angela G Fleischman

All Authors:
Andrew Oliver,Kenza El Alaoui,Carolyn Haunschild,Julio Avelar-Barragan,Laura F Mendez Luque,Katrine Whiteson,Angela G Fleischman

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