国内团队:睡眠不足、经常午睡或可增加炎症性肠病风险
创作:芥末 审核:芥末 2022年11月22日
  • 纳入英国生物银行研究的近45万名参与者,中位随访12.0年,共诊断炎症性肠病(IBD)2604例,其中806例克罗恩病(CD)、1798例溃疡性结肠炎(UC);
  • 睡眠时长与IBD风险呈非线性关联,与每天睡眠7小时相比,每天睡眠少于5小时可使IBD、CD、UC风险分别升高36%、53%和29%;
  • 与白天不午睡相比,白天午睡的参与者患IBD、CD、UC的风险分别升高13%、25%和9%;
  • IBD多基因风险评分较高的人群中,睡眠时长、白天是否午睡与IBD风险的关系更显著。
主编推荐语
芥末
睡眠在保持身心健康方面起着重要作用。睡眠不足与包括消化系统疾病在内的多种疾病的发生发展相关。然而,目前基于人群的睡眠时间和炎症性肠病(IBD)风险间关系的证据较少,且相互间不一致,而且也缺乏白天午睡是否影响IBD风险的研究。浙江大学公共卫生学院李雪、陈杰与中南大学湘雅三医院王晓艳及其团队近日在Alimentary Pharmacology and Therapeutics发表最新研究,利用英国生物银行研究中近45万人的随访数据,发现睡眠不足和白天午睡显著增加IBD的患病风险。
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Sleep duration and daytime napping in relation to incident inflammatory bowel disease: a prospective cohort study

睡眠时长和白天午睡与炎症性肠病发病率的关系:一项前瞻性队列研究

10.1111/apt.17285

2022-11-09, Article

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Background: Sleep dysregulation has been linked to gastrointestinal dysfunction and inflammation.
Aims: To explore the associations between sleep duration, daytime napping and inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC).
Methods: Exposure information was obtained from the baseline questionnaire. Sleep duration was coded as continuous and categorical (≤5, 6, 7, 8, ≥9 h/day) variables. Daytime napping was defined as yes (sometimes/usually) and no (never/rarely). Incident IBD cases were defined from primary care and hospital inpatient records. Polygenic risk scores (PRS) for the outcomes were constructed and categorised into low, intermediate and high risk. Hazard ratio (HR) and confidence interval (CI) were estimated using Cox proportional hazard regression.
Results: The analysis included 2604 incident IBD cases (806 CD and 1798 UC) with a median follow-up of 12.0 years. Comparing sleep duration ≤5 with 7 h/day, the HR of IBD, CD and UC was 1.36 (95% CI, 1.17–1.59), 1.53 (95% CI, 1.17–2.00) and 1.29 (95% CI, 1.07–1.56), respectively. Comparing participants with and without daytime napping, the HR of IBD, CD and UC was 1.13 (95% CI, 1.05–1.23), 1.25 (95% CI, 1.08–1.44) and 1.09 (95% CI, 0.90–1.20), respectively. No interaction of sleep duration and daytime napping with PRS was detected. However, the associations appeared stronger in individuals with high rather than low PRS.
Conclusions: This study reveals positive associations between short sleep duration and daytime napping and IBD risk.

First Authors:
Shuai Yuan,Yuhao Sun

Correspondence Authors:
Jie Chen,Xiaoyan Wang,Xue Li

All Authors:
Shuai Yuan,Yuhao Sun,Xiao Tan,Jiawei Geng,Jing Sun,Xuejie Chen,Lili Yu,Jiayi Wang,Xuan Zhou,Therese Hesketh,Susanna C Larsson,Jie Chen,Xiaoyan Wang,Xue Li,Zhanju Liu

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