丙烯酰胺摄入或增加女性绝经前的乳腺癌风险
创作:aluba 审核:aluba 2022年09月11日
  • 纳入80597名法国女性(平均40.8岁),平均随访8.8年间共确诊1016例乳腺癌(431例绝经前、585例绝经后);
  • 通过多次24小时饮食回顾评估丙烯酰胺的摄入量,平均每日的丙烯酰胺摄入量为30.1μg,主要来自咖啡、薯条、薯片、甜点、蛋糕、面包;
  • 相比于丙烯酰胺饮食摄入量最低者,丙烯酰胺饮食摄入量最高者的乳腺癌风险显著增加21%,尤其是绝经前乳腺癌风险显著增加40%;
  • 丙烯酰胺摄入与(总及绝经前)雌激素受体阳性乳腺癌风险呈正相关。
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aluba
American Journal of Clinical Nutrition上发表的一项前瞻性队列研究结果,对超过8万名法国女性进行9年左右的随访后发现,丙烯酰胺饮食摄入量越高,绝经前的乳腺癌风险越高。
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Dietary exposure to acrylamide and breast cancer risk: results from the NutriNet-Santé cohort

丙烯酰胺饮食暴露与乳腺癌风险:NutriNet-Santé队列的结果

10.1093/ajcn/nqac167

2022-09-02, Article

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Background: Acrylamide is classified as a probable human carcinogen by the International Agency for Research on Cancer but epidemiologic evidence on the carcinogenicity of acrylamide from dietary sources is limited.
Objectives: This study aimed to investigate the associations between dietary acrylamide and breast cancer risk in the NutriNet-Santé cohort, accounting for menopausal and hormone receptor status.
Methods: This prospective cohort study included 80,597 French females (mean ± SD age at baseline: 40.8 ± 14 y) during a mean ± SD follow-up of 8.8 ± 2.3 y. Acrylamide intake was evaluated using repeated 24-h dietary records (n ± SD = 5.5 ± 3.0), linked to a comprehensive food composition database. Associations between acrylamide intake and breast cancer risk (overall, premenopausal, and postmenopausal) were assessed by Cox hazard models adjusted for known risk factors (sociodemographic, anthropometric, lifestyle, medical history, and nutritional factors).
Results: The mean ± SD dietary acrylamide intake was 30.1 ± 21.9 µg/d (main contributors: coffee, potato fries and chips, pastries, cakes, bread). During follow-up, 1016 first incident breast cancer cases were diagnosed (431 premenopausal, 585 postmenopausal). A borderline significant positive association was observed between dietary acrylamide exposure and breast cancer risk overall (HR for quartile 4 compared with 1: 1.21; 95% CI: 1.00, 1.47) and a positive association was observed with premenopausal cancer (HRQ4vs.Q1: 1.40; 95% CI: 1.04, 1.88). Restricted cubic spline analyses suggested evidence for nonlinearity of these associations, with higher HRs for intermediate (quartile 2) and high (quartile 4) exposures. Receptor-specific analyses revealed positive associations with estrogen receptor–positive breast cancer (total and premenopausal). Acrylamide intake was not associated with postmenopausal breast cancer.
Conclusions: Results from this large prospective cohort study suggest a positive association between dietary acrylamide and breast cancer risk, especially in premenopausal females, and provide new insights that support continued mitigation strategies to reduce the content of acrylamide in food. This trial was registered at clinicaltrials.gov as NCT03335644.

First Authors:
Alice Bellicha

Correspondence Authors:
Alice Bellicha

All Authors:
Alice Bellicha,Gaëlle Wendeu-Foyet,Xavier Coumoul,Meriem Koual,Fabrice Pierre,Françoise Guéraud,Laurent Zelek,Charlotte Debras,Bernard Srour,Laury Sellem,Emmanuelle Kesse-Guyot,Chantal Julia,Pilar Galan,Serge Hercberg,Mélanie Deschasaux-Tanguy,Mathilde Touvier

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