一文读懂肛门癌及其治疗(综述)
创作:orchid 审核:mildbreeze 07月01日
  • 肛门癌(CAC)发病率每年上升2.7%,应筛查高危人群,≥35岁的HIV患者均可进行筛查,PET/CT等方法可用于CAC分期;
  • 乳头瘤病毒(HPV)感染是CAC发生的主要危险因素,HPV多价疫苗对预防CAC有重要意义;
  • 免疫治疗对部分进展期和转移性CAC患者有效,同步放化疗为患者器官保存奠定基础,需考虑放化疗可能导致的长期毒性,及其所需的支持性和预防性护理;
  • CAC的研究进展也有助于其他HPV相关恶性肿瘤的研究。
主编推荐语
mildbreeze
肛门癌被认为是一种罕见疾病,但近年来其发病率逐年升高。Journal of Clinical Oncology近期发表的综述,探讨了肛门癌的概况、筛查和治疗等方面的现状。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Anal Cancer: Emerging Standards in a Rare Rare Disease

肛门癌:一种罕见疾病的新标准

10.1200/JCO.21.02566

06-01, Review

Abstract & Authors:展开

Abstract:收起
The social stigma surrounding an anal cancer diagnosis has traditionally prevented open discussions about this disease. However, as recent treatment options and an increasing rate of diagnoses are made worldwide, awareness is growing. In the United States alone, 9,090 individuals were expected to be diagnosed with anal cancer in 2021. The US annual incidence of squamous cell carcinoma of the anus continues to increase by 2.7% yearly, whereas the mortality rate increases by 3.1%. The main risk factor for anal cancer is a human papillomavirus infection; those with chronic immunosuppression are also at risk. Patients with HIV are 19 times more likely to develop anal cancer compared with the general population. In this review, we have provided an overview of the carcinoma of the anal canal, the role of screening, advancements in radiation therapy, and current trials investigating acute and chronic treatment–related toxicities. This article is a comprehensive approach to presenting the existing data in an effort to encourage continuous international interest in anal cancer.

First Authors:
Cathy Eng

Correspondence Authors:
Cathy Eng

All Authors:
Cathy Eng,Kristen K Ciombor,May Cho,Jennifer A Dorth,Lakshmi N Rajdev,David P Horowitz,Marc J Gollub,Alexandre A Jácome,Natalie A Lockney,Roberta L Muldoon,Mary Kay Washington,Brittany A O'Brian,Amala Benny,Cody M Lebeck Lee,Al B Benson III,Karyn A Goodman,Van Karlyle Morris

评论