程蜀琳+陈洛南+张晨虹:脂肪肝患者肠道菌群网络对运动和饮食干预的响应
  • 通过随机对照临床试验,研究8.6个月的运动和/或饮食干预对非酒精性脂肪肝病患者肠道菌群的影响;
  • 运动和/或饮食干预改变了患者菌群结构和功能,这与肝脂含量和短链脂肪酸的变化相关;
  • 菌群网络分析表明,干预提高了肠道微生态系统稳定性,从而影响肝脂含量的改善,其中运动+饮食干预使基石分类群更加多样和稳定,而运动或饮食的单独干预增加了网络的连接性和稳健性;
  • 个体的基线肠道菌群网络可预测干预对肝脂含量的个体化影响。
主编推荐语
mildbreeze
运动和饮食干预是治疗非酒精性脂肪肝病(NAFLD)的方法,然而,运动和饮食干预如何影响患者的肠道菌群?目前还存在很多未知。Nature Communications最新发表了来自上海交通大学运动转化医学中心程蜀琳团队、中国科学院分子细胞科学卓越创新中心陈洛南团队与上海交通大学生命科学技术学院张晨虹团队的合作研究成果,通过开展随机对照试验对这一问题进行了探索,揭示了运动和饮食干预对NAFLD患者肠道菌群网络的影响,以及菌群网络用于预测个体干预效果的潜力,为NAFLD的个性化治疗带来了新启示。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease

非酒精性脂肪性肝病患者中微生物组网络对运动和饮食干预的反应的随机对照试验

10.1038/s41467-022-29968-0

05-10, Article

Abstract & Authors:展开

Abstract:收起
Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 in Aerobic exercise, 22 in Diet, 23 in Aerobic exercise + Diet, 18 in No Intervention). We show that combined aerobic exercise and diet intervention are associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increase network connectivity and robustness between taxa. No adverse effects were observed with the interventions. In addition, in exploratory ad-hoc analyses we find that not all subjects responded to the intervention in a similar manner, when using differentially altered gut microbe amplicon sequence variants abundance to classify the responders and low/non-responders. A personalized gut microbial network at baseline could predict the individual responses in liver fat to exercise intervention. Our findings suggest an avenue for developing personalized intervention strategies for treatment of NAFLD based on host-gut microbiome ecosystem interactions, however, future studies with large sample size are needed to validate these discoveries. The Trial Registration Number is ISRCTN 42622771.

First Authors:
Runtan Cheng,Lu Wang

Correspondence Authors:
Chenhong Zhang,Luonan Chen,Sulin Cheng

All Authors:
Runtan Cheng,Lu Wang,Shenglong Le,Yifan Yang,Can Zhao,Xiangqi Zhang,Xin Yang,Ting Xu,Leiting Xu,Petri Wiklund,Jun Ge,Dajiang Lu,Chenhong Zhang,Luonan Chen,Sulin Cheng

评论