Nature子刊:较高的血液n-3脂肪酸水平与较低的死亡率相关
创作:aluba 审核:aluba 2021年05月02日
  • 纳入17项前瞻性队列研究进行荟萃分析,共涉及42,466名受试者,中位随访16年期间,共发生15,720例死亡;
  • 校正多变量后,相比于血液长链n-3脂肪酸(包括二十碳五烯酸、二十二碳五烯酸、二十二碳六烯酸)水平最低者,血液长链n-3脂肪酸水平最高者的全因死亡风险显著降低15-18%;
  • 较高的血液长链n-3脂肪酸水平与较低的心血管疾病、癌症及其它原因的死亡风险相关;
  • α-亚麻酸与全因死亡及特因死亡风险之间无显著关联。
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aluba
n-3脂肪酸对健康的影响存在争议。Nature Communications上发表的一项荟萃分析结果,总结了17项前瞻性队列研究的数据(超过4万名受试者,中位随访16年)后发现,较高的血液长链n-3脂肪酸(20-22碳,而非18碳)水平与较低的全因死亡率、心血管疾病死亡率及癌症死亡率相关。
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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

17项前瞻性研究中,血液n-3脂肪酸水平与全因死亡率及特因死亡率的关联

10.1038/s41467-021-22370-2

2021-04-22, Article

Abstract & Authors:展开

Abstract:收起
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

First Authors:
William S Harris

Correspondence Authors:
William S Harris

All Authors:
William S Harris,Nathan L Tintle,Fumiaki Imamura,Frank Qian,Andres V Ardisson Korat,Matti Marklund,Luc Djoussé,Julie K Bassett,Pierre-Hugues Carmichael,Yun-Yu Chen,Yoichiro Hirakawa,Leanne K Küpers,Federica Laguzzi,Maria Lankinen,Rachel A Murphy,Cécilia Samieri,Mackenzie K Senn,Peilin Shi,Jyrki K Virtanen,Ingeborg A Brouwer,Kuo-Liong Chien,Gudny Eiriksdottir,Nita G Forouhi,Johanna M Geleijnse,Graham G Giles,Vilmundur Gudnason,Catherine Helmer,Allison Hodge,Rebecca Jackson,Kay-Tee Khaw,Markku Laakso,Heidi Lai,Danielle Laurin,Karin Leander,Joan Lindsay,Renata Micha,Jaako Mursu,Toshiharu Ninomiya,Wendy Post,Bruce M Psaty,Ulf Risérus,Jennifer G Robinson,Aladdin H Shadyab,Linda Snetselaar,Aleix Sala-Vila,Yangbo Sun,Lyn M Steffen,Michael Y Tsai,Nicholas J Wareham,Alexis C Wood,Jason H Y Wu,Frank Hu,Qi Sun,David S Siscovick,Rozenn N Lemaitre,Dariush Mozaffarian,The Fatty Acids and Outcomes Research Consortium (FORCE)

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