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The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
William S Harris
William S Harris
William S Harris,Nathan L Tintle,Fumiaki Imamura,Frank Qian,Andres V Ardisson Korat,Matti Marklund,Luc Djoussé,Julie K Bassett,Pierre-Hugues Carmichael,Yun-Yu Chen,Yoichiro Hirakawa,Leanne K Küpers,Federica Laguzzi,Maria Lankinen,Rachel A Murphy,Cécilia Samieri,Mackenzie K Senn,Peilin Shi,Jyrki K Virtanen,Ingeborg A Brouwer,Kuo-Liong Chien,Gudny Eiriksdottir,Nita G Forouhi,Johanna M Geleijnse,Graham G Giles,Vilmundur Gudnason,Catherine Helmer,Allison Hodge,Rebecca Jackson,Kay-Tee Khaw,Markku Laakso,Heidi Lai,Danielle Laurin,Karin Leander,Joan Lindsay,Renata Micha,Jaako Mursu,Toshiharu Ninomiya,Wendy Post,Bruce M Psaty,Ulf Risérus,Jennifer G Robinson,Aladdin H Shadyab,Linda Snetselaar,Aleix Sala-Vila,Yangbo Sun,Lyn M Steffen,Michael Y Tsai,Nicholas J Wareham,Alexis C Wood,Jason H Y Wu,Frank Hu,Qi Sun,David S Siscovick,Rozenn N Lemaitre,Dariush Mozaffarian,The Fatty Acids and Outcomes Research Consortium (FORCE)