程功团队:共生微生物如何影响虫媒对病毒的易感性(综述)
  • 共生微生物影响节肢动物媒介与虫媒病毒的互作,直接或间接地影响虫媒对病毒的易感性;
  • 虫媒的肠道微生物主要通过调节肠道免疫应答(抗菌肽生成和活性氧活化)、改变肠屏障物理状态(围食膜基质和黏蛋白层)、产生特定代谢物,来调控病毒对肠上皮细胞的感染;
  • 在肠道以外的血腔组织中,内共生菌(如沃尔巴克氏体)可能通过调节免疫应答或脂代谢来影响病毒复制;
  • 改造肠道共生菌等靶向虫媒肠道菌群的策略,或能用于防控虫媒病毒。
主编推荐语
mildbreeze
蚊子、蜱虫等节肢动物媒介,是虫媒病毒的携带和传播者,人类被其叮咬后可能会引起感染甚至死亡。近年研究表明,虫媒中的共生微生物能影响其宿主与虫媒病毒的相互作用,影响虫媒对病毒感染的易感性。清华大学程功团队在《Trends in Parasitology》发表的一篇最新综述对相关研究的进展进行了回顾,总结了其中的生物学机制,对用微生物作为虫媒病毒的防控手段以及该领域面临的研究挑战进行了展望和讨论。推荐专业人士参考学习。
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Roles of Symbiotic Microorganisms in Arboviral Infection of Arthropod Vectors

共生微生物在虫媒病毒感染节肢动物媒介中的作用

10.1016/j.pt.2020.04.009

2020-05-05, Article

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Arthropod vectors serve as native reservoirs and transmitters of hundreds of ar- boviruses. In arthropod vectors, symbiotic microorganisms residing in the gut lumen and/or hemocoelic tissues maintain complicated relationships with their host and influence multiple aspects of vector physiology. Recently, accumulat- ing evidence has established an important role for symbiotic microorganisms in vector–virus interactions which could potentially be used to control viral trans- mission. Herein, we review recent progress on symbiotic microbe–arbovirus in- teractions and summarize the molecular mechanisms by which commensal microbes act on hosts and arboviruses. Understanding the sophisticated inter- actions among arthropod vectors, microbiota, and arboviruses may offer new strategies for the prevention of arboviral diseases in the future.

First Authors:
Chunhong Yin,Peng Sun

Correspondence Authors:
Gong Cheng

All Authors:
Chunhong Yin,Peng Sun,Xi Yu,Penghua Wang,Gong Cheng

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