创作:Epi汪 审核:Epi汪 2021年06月04日
  • 纳入来自18个国家43个研究机构的孕产妇数据,其中706名被诊断为新冠病毒阳性,有1424名阴性对照;
  • 阳性组孕妇发生先兆子痫/子痫、严重感染、重症监护病房住院、孕产妇死亡、早产的风险均在一定程度上增加;
  • 而新生儿重症指数增高、新生儿并发症等风险也增高;
  • 在阳性孕妇中,仅13%的新生儿病毒检测呈阳性;
  • 在这些病毒阳性新生儿中,剖宫产比例更高,且非母乳喂养的比例增加。
JAMA Pediatrics [IF:26.796]

Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study



2021-04-22, Article

Abstract & Authors:展开

Importance: Detailed information about the association of COVID-19 with outcomes in pregnant individuals compared with not-infected pregnant individuals is much needed.
Objective: To evaluate the risks associated with COVID-19 in pregnancy on maternal and neonatal outcomes compared with not-infected, concomitant pregnant individuals.
Design, Setting, and Participants: In this cohort study that took place from March to October 2020, involving 43 institutions in 18 countries, 2 unmatched, consecutive, not-infected women were concomitantly enrolled immediately after each infected woman was identified, at any stage of pregnancy or delivery, and at the same level of care to minimize bias. Women and neonates were followed up until hospital discharge.
Exposures: COVID-19 in pregnancy determined by laboratory confirmation of COVID-19 and/or radiological pulmonary findings or 2 or more predefined COVID-19 symptoms.
Main Outcomes and Measures: The primary outcome measures were indices of (maternal and severe neonatal/perinatal) morbidity and mortality; the individual components of these indices were secondary outcomes. Models for these outcomes were adjusted for country, month entering study, maternal age, and history of morbidity.
Results: A total of 706 pregnant women with COVID-19 diagnosis and 1424 pregnant women without COVID-19 diagnosis were enrolled, all with broadly similar demographic characteristics (mean [SD] age, 30.2 [6.1] years). Overweight early in pregnancy occurred in 323 women (48.6%) with COVID-19 diagnosis and 554 women (40.2%) without. Women with COVID-19 diagnosis were at higher risk for preeclampsia/eclampsia (relative risk [RR], 1.76; 95% CI, 1.27-2.43), severe infections (RR, 3.38; 95% CI, 1.63-7.01), intensive care unit admission (RR, 5.04; 95% CI, 3.13-8.10), maternal mortality (RR, 22.3; 95% CI, 2.88-172), preterm birth (RR, 1.59; 95% CI, 1.30-1.94), medically indicated preterm birth (RR, 1.97; 95% CI, 1.56-2.51), severe neonatal morbidity index (RR, 2.66; 95% CI, 1.69-4.18), and severe perinatal morbidity and mortality index (RR, 2.14; 95% CI, 1.66-2.75). Fever and shortness of breath for any duration was associated with increased risk of severe maternal complications (RR, 2.56; 95% CI, 1.92-3.40) and neonatal complications (RR, 4.97; 95% CI, 2.11-11.69). Asymptomatic women with COVID-19 diagnosis remained at higher risk only for maternal morbidity (RR, 1.24; 95% CI, 1.00-1.54) and preeclampsia (RR, 1.63; 95% CI, 1.01-2.63). Among women who tested positive (98.1% by real-time polymerase chain reaction), 54 (13%) of their neonates tested positive. Cesarean delivery (RR, 2.15; 95% CI, 1.18-3.91) but not breastfeeding (RR, 1.10; 95% CI, 0.66-1.85) was associated with increased risk for neonatal test positivity.
Conclusions and Relevance: In this multinational cohort study, COVID-19 in pregnancy was associated with consistent and substantial increases in severe maternal morbidity and mortality and neonatal complications when pregnant women with and without COVID-19 diagnosis were compared. The findings should alert pregnant individuals and clinicians to implement strictly all the recommended COVID-19 preventive measures.

First Authors:
José Villar

Correspondence Authors:
Aris T Papageorghiou

All Authors:
José Villar,Shabina Ariff,Robert B Gunier,Ramachandran Thiruvengadam,Stephen Rauch,Alexey Kholin,Paola Roggero,Federico Prefumo,Marynéa Silva do Vale,Jorge Arturo Cardona-Perez,Nerea Maiz,Irene Cetin,Valeria Savasi,Philippe Deruelle,Sarah Rae Easter,Joanna Sichitiu,Constanza P Soto Conti,Ernawati Ernawati,Mohak Mhatre,Jagjit Singh Teji,Becky Liu,Carola Capelli,Manuela Oberto,Laura Salazar,Michael G Gravett,Paolo Ivo Cavoretto,Vincent Bizor Nachinab,Hadiza Galadanci,Daniel Oros,Adejumoke Idowu Ayede,Loïc Sentilhes,Babagana Bako,Mónica Savorani,Hellas Cena,Perla K García-May,Saturday Etuk,Roberto Casale,Sherief Abd-Elsalam,Satoru Ikenoue,Muhammad Baffah Aminu,Carmen Vecciarelli,Eduardo A Duro,Mustapha Ado Usman,Yetunde John-Akinola,Ricardo Nieto,Enrico Ferrazi,Zulfiqar A Bhutta,Ana Langer,Stephen H Kennedy,Aris T Papageorghiou