Science:出生后不易生病,感谢你妈的好细菌?
创作:Mona 审核:大月半 2016年03月18日
  • 在处于妊娠期的雌鼠体内定植细菌,能够帮助后代小鼠形成先天免疫,但对获得性免疫没有影响;
  • 母体菌群塑造了后代的免疫系统,妊娠期定植细菌增加后代肠道3族先天淋巴细胞和F4/80+CD11c单核细胞数量;
  • 母体内定植细菌改变了后代肠道内基因的转录,提高了编码肠上皮细胞抗菌肽等基因的表达;
  • 菌群在母体怀孕期间和母乳中传播给后代,这个过程依赖于母体的抗体,
  • 孕期接受细菌定植的雌鼠,其后代更不易发生炎症反应和肠道微生物的渗透。
#微生物与免疫系统#
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Science [IF:47.728]

The maternal microbiota drives early postnatal innate immune development

母鼠菌群驱动新生小鼠早期先天免疫的发育

10.1126/science.aad2571

2016-03-18, Article

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Postnatal colonization of the body with microbes is assumed to be the main stimulus to postnatal immune development. By transiently colonizing pregnant female mice, we show that the maternal microbiota shapes the immune system of the offspring. Gestational colonization increases intestinal group 3 innate lymphoid cells and F4/80+CD11c+ mononuclear cells in the pups. Maternal colonization reprograms intestinal transcriptional profiles of the offspring, including increased expression of genes encoding epithelial antibacterial peptides and metabolism of microbial molecules. Some of these effects are dependent on maternal antibodies that potentially retain microbial molecules and transmit them to the offspring during pregnancy and in milk. Pups born to mothers transiently colonized in pregnancy are better able to avoid inflammatory responses to microbial molecules and penetration of intestinal microbes.

First Authors:
M Gomez de Aguero,Stephanie C Ganal-Vonarburg,Andrew J Macpherson

Correspondence Authors:
Andrew J Macpherson

All Authors:
M Gomez de Aguero,Stephanie C Ganal-Vonarburg,Tobias Fuhrer,Sandra Rupp,Yasuhiro Uchimura,Hai Li,Anna Steinert,Mathias Heikenwälder,Siegfried Hapfelmeier,Uwe Sauer,Kathy Mccoy,Andrew J Macpherson

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