马现仓+贾慧珏等:精神分裂症患者的肠道微生物组特征
  • 收集90例未经治疗的精神分裂症患者和81例对照的粪便样本,通过宏基因组关联分析鉴定出83个相对丰度有显著差异的OTU;
  • 患者菌群中,兼性厌氧菌和口腔菌增多,短链脂肪酸合成、色氨酸代谢、多种神经递质的合成/降解等功能潜力发生改变;
  • 包含26个OTU的诊断模型可较准确的区分患者和对照(AUC=0.896),并在测试队列中得到确认(AUC=0.765);
  • 移植患者中富集的前庭链球菌,可诱导小鼠的精神分裂症样行为、改变外周神经递质水平。
主编推荐语
mildbreeze
肠道菌群可作用于肠脑轴,与神经疾病的发生存在密切关联。Nature Communications最新发表了来自西安交大一附医院马现仓团队和华大基因贾慧珏团队等的合作研究,鉴定出精神分裂症相关的人肠道微生物组的组成和功能特征,为进一步研究其发病机制和治疗方法提供了新线索。有兴趣的读者不妨结合阅读一下他们团队去年发表的一篇相关论文(查看文章),会有更多收获。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

Metagenome-wide association of gut microbiome features for schizophrenia

精神分裂症肠道微生物组特征的宏基因组关联

10.1038/s41467-020-15457-9

2020-03-31, Article

Abstract & Authors:展开

Abstract:收起
Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.

First Authors:
Feng Zhu,Yanmei Ju,Wei Wang,Qi Wang,Ruijin Guo

Correspondence Authors:
Karsten Kristiansen,Huijue Jia,Xiancang Ma

All Authors:
Feng Zhu,Yanmei Ju,Wei Wang,Qi Wang,Ruijin Guo,Qingyan Ma,Qiang Sun,Yajuan Fan,Yuying Xie,Zai Yang,Zhuye Jie,Binbin Zhao,Liang Xiao,Lin Yang,Tao Zhang,Junqin Feng,Liyang Guo,Xiaoyan He,Yunchun Chen,Ce Chen,Chengge Gao,Xun Xu,Huanming Yang,Jian Wang,Yonghui Dang,Lise Madsen,Susanne Brix,Karsten Kristiansen,Huijue Jia,Xiancang Ma

评论