人体微生物组,婴儿健康的朋友还是敌人(综述)
创作:Epi汪 审核:Epi汪 2021年09月17日
  • 在早产儿中,微生物组、肠和脑的发育是“平行”的,早产儿的菌群不同于足月儿,可能对正常发育很重要;
  • 菌群影响免疫系统的发育,因此造成的炎症反应可能是许多早产儿疾病发生的共同途径;
  • 由于存在肠道-菌群-大脑轴,任何改变菌群的干预都需要在长期神经发育评估的背景下开展,而不是仅关注特定的疾病;
  • 益生菌只是改变菌群的一种方法,其他方式还包括母乳喂养、抗生素管理等;
  • 未来研究应关注菌群生物标志物的发展,其具有治疗前景。
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Epi汪
人体微生物组,在婴儿不成熟的肠道和免疫系统中,可能造成毁灭性的疾病和严重的神经损伤,但是其也是促进婴儿健康发展的重要因素。本综述全面总结了目前认识到的微生物组对婴儿健康的各方面影响,尤其是其在早产儿各类疾病中的潜在作用。具有重要的参考借鉴价值。
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The microbiome, guard or threat to infant health

微生物组,婴儿健康的保护还是威胁

10.1016/j.molmed.2021.08.002

2021-09-10, Article

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Despite improvements in survival for very low birthweight (VLBW) premature infants, there continues to be significant morbidity for these infants at remarkable cost to the healthcare system. Concurrent development of the preterm infant intestine alongside the gut microbiome in the clinical setting rather than in the protected in utero environment where it would usually occur creates significant vulnerabilities for the infant's immature intestine and immune system, resulting in devastating illness and neurological injury. However, the microbiome also has the capacity to promote healthy development. Studies of parallel gut microbiome and preterm infant development have given key insight into the impact of the microbiome on intestinal as well as neural development and may provide potential therapeutic targets to prevent preterm infant morbidities.

First Authors:
Melinique Walls Castellanos

Correspondence Authors:
Erika C Claud

All Authors:
Melinique Walls Castellanos,Erika C Claud

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