武汉同济医院:多吃鱼或可改善癌患生存 (综述)
创作:Bingbing 审核:Bingbing 02月21日
  • 纳入共21项队列研究,与最低摄入组相比,摄入鱼类最高的组与较低的卵巢癌死亡率、总体死亡率有关;
  • 摄入海洋源n-3多不饱和脂肪酸(PUFAs),而不是总n-3 PUFAs,对整体癌症(尤其是前列腺癌)存活具有显著的保护效应;
  • 基于剂量依赖的荟萃分析表明,膳食鱼、海洋源n-3 PUFAs与整体癌症存活分别具有非线性、线性相关性;
  • 膳食鱼和海洋源n-3 PUFAs的摄入对癌患存活具有保护效果。
主编推荐语
Bingbing
华中科技大学同济医学院附属同济医院程黎明和Jiaoyuan Li与团队的研究成果。鱼以及n-3多不饱和脂肪酸是日常餐桌食物。本文针对性的探究了鱼以及n-3多不饱和脂肪酸与癌症患者生存率的关系。荟萃分析结果显示,摄入鱼和海洋源n-3PUFAs对癌患的存活具有一定的保护作用。
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Dietary fish and omega-3 polyunsaturated fatty acids intake and cancer survival: A systematic review and meta-analysis

摄入鱼和n-3多不饱和脂肪酸与癌症生存:系统综述与荟萃分析

10.1080/10408398.2022.2029826

01-24, Review

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Fish and omega-3 polyunsaturated fatty acids (PUFA) have been suggested to play a role in improving cancer prognosis. However, results from epidemiological studies remain inconsistent. Here we assess the association between dietary fish and/or omega-3 PUFAs intake and cancer prognosis with meta-analysis of observational studies. A systematic search of related publications was performed using PubMed and Web of Science databases. Hazard ratios (HR) and 95% confidence intervals (CI) were extracted and then pooled using a random-effect model. Potential linear and non-linear dose-response relationships were explored using generalized least squares estimation and restricted cubic splines. As a result, 21 cohort studies were included in our analysis. Compared to the lowest category, the highest category of fish intake was associated with a significant lower mortality in patients with ovarian cancer (n = 1, HR = 0.74, 95% CI: 0.57–0.95) and overall cancer (n = 12, HR = 0.87, 95% CI: 0.81–0.94). Marine omega-3 PUFAs intake rather than total omega-3 PUFAs intake showed significant protective effects on survival of overall cancer (n = 8, HR = 0.81, 95% CI: 0.71–0.94), in particular prostate cancer (n = 2, HR = 0.62, 95% CI: 0.46–0.82). Dose-response meta-analysis indicated a nonlinear and a linear relationship between fish intake, as well as marine omega-3 PUFAs intake, and overall cancer survival, respectively. In conclusion, our analysis demonstrated a protective effect of dietary fish and marine omega-3 PUFAs consumption on cancer survival.

First Authors:
Yi Wang

Correspondence Authors:
Jiaoyuan Li,Liming Cheng

All Authors:
Yi Wang,Ke Liu,Tingting Long,Jieyi Long,Ying Li,Jiaoyuan Li,Liming Cheng

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