北京友谊医院:脂肪肝病与女性IBS风险增加相关
  • 纳入396838参与者,通过脂肪肝指数(FLI)对NAFLD进行评估,共发现153203名NAFLD患者(FLI≥60);
  • 在中位12.4年的随访期间,共确诊7129例IBS;
  • 多变量校正后,与非NAFLD者相比,NAFLD患者的IBS风险显著增加了13% ;
  • 与FLI评分最低者相比,FLI评分最高者的IBS风险显著增加了21%;
  • FLI评分每增加一个标准差,与IBS风险增加8%显著相关;
  • 敏感性分析和亚组分析的结果类似,上述关联仅可在女性中观察到。
主编推荐语
aluba
北京友谊医院的朱圣韬团队在BMC Medicine上发表的一项前瞻性队列研究结果,对近40万名参与者进行12年左右的随访后发现,非酒精性脂肪性肝病(NAFLD)与女性(而非男性)的IBS风险增加相关。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
BMC Medicine [IF:11.15]

Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

非酒精性脂肪肝与IBS的风险增加有关:一项前瞻性队列研究

10.1186/s12916-022-02460-8

2022-08-22, Article

Abstract & Authors:展开

Abstract:收起
Background: The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospective association of non-alcoholic fatty liver degree as well as NAFLD with incident IBS in a large-scale population-based cohort.
Methods: Participants free of IBS, coeliac disease, inflammatory bowel disease, alcoholic liver disease, and any cancer at baseline from the UK Biobank were included. Non-alcoholic fatty liver degree was measured by a well-validated fatty liver index (FLI), with FLI ≥ 60 as an indicator of NAFLD. Primary outcome was incident IBS. Cox proportional hazard model was used to investigate the associated risk of incident IBS.
Results: Among 396,838 participants (mean FLI was 48.29 ± 30.07), 153,203(38.6%) were with NAFLD diagnosis at baseline. During a median of 12.4-year follow-up, 7129 cases of incident IBS were identified. Compared with non-NAFLD, NAFLD patients showed a 13% higher risk of developing IBS (HR = 1.13, 95%CI: 1.05–1.17) after multivariable adjustment. Compared with the lowest, the highest FLI quartile was associated with a significantly increased risk of IBS (HRQ4 VS Q1 = 1.21, 1.13–1.30, Ptrend < 0.001). Specifically, the positive association between non-alcoholic fatty liver degree and IBS was also observed by per SD change of FLI (adjusted HR = 1.08, 1.05–1.10). Further sensitivity analysis and subgroup analysis indicated similar results, with the positive association particularly observed in females, but not in males.
Conclusions: High degree of non-alcoholic fatty liver as well as non-alcoholic fatty liver disease is associated with increased risk of incident IBS. Further studies are warranted to confirm the findings and elucidate the underlying biological mechanisms.

First Authors:
Shanshan Wu

Correspondence Authors:
Shengtao Zhu

All Authors:
Shanshan Wu,Changzheng Yuan,Zhirong Yang,Si Liu,Qian Zhang,Shutian Zhang,Shengtao Zhu

评论