肠道菌群产物调节霍乱弧菌运动模式
创作:周旸 审核:周旸 06月05日
  • 来自健康人粪便的小分子可以抑制霍乱弧菌生长,抑制其运动,促进生物膜形成;
  • 人粪便提取物抑制霍乱弧菌的运动和黏蛋白穿透能力,被粪便提取物抑制的霍乱弧菌基因中有39%与运动能力相关;
  • 柠檬酸肠杆菌分泌的小分子中,含有可抑制霍乱弧菌运动和黏蛋白穿透能力的成员;
  • 普通拟杆菌(B. vulgatus)和含有该菌的人造菌群,其产生的小分子可以增加霍乱弧菌运动能力;
  • 肠道菌群产生的小分子,对共生菌群-病原菌互作有广泛和显著的影响。
主编推荐语
周旸
肠道菌群分泌的小分子很可能是介导共生细菌-致病菌互作的关键物质。Gut Microbes近期发表的研究发现,健康人肠道提取物和肠道细菌培养液上清中,含有可以调节霍乱弧菌运动和黏膜穿透的小分子物质,虽然肠道菌群分泌的小分子对于霍乱弧菌的生长和运动呈抑制作用,但不同细菌产物的影响并不一致。该研究从菌群、菌株代谢水平解读共生菌-霍乱弧菌互作分子机制,对于深入研究肠道内细菌间互作、肠道细菌致病机制调控均有重要参考价值。
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Gut Microbes [IF:10.245]

Bioactive small molecules produced by the human gut microbiome modulate sessile and planktonic lifestyles

人肠道菌群产生的小分子物质调节霍乱弧菌的固着和浮游生活方式

10.1080/19490976.2021.1918993

05-19, Article

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Humans live in symbiosis with a diverse community of microorganisms, which has evolved to carry out many specific tasks that benefit the host, including protection against invading pathogens. Within the chemical diversity of the gastrointestinal tract, small molecules likely constitute chemical cues for the communication between the microbiota and pathogens. Therefore, we sought to investigate if molecules produced by the human gut microbiota show biological activity against the human pathogen . To probe the effects of the gut metabolome on , we investigated its response to small-molecule extracts from human feces, from a complex bacterial community cultivated , and from culture supernatants of , and . Using RNA sequencing, we determined the impact of the human gut metabolome on global gene expression. Among the genes downregulated in the presence of the fecal extract, the most overrepresented functional category was cell motility, which accounted for 39% of repressed genes. Repression of motility by the fecal extract was confirmed phenotypically, and extracts reproduced this phenotype. A complex microbial community led to increased motility, as did extracts from , a species present in this community. Accordingly, mucin penetration was also repressed by fecal and extracts, suggesting that the phenotypes observed may have implications for host colonization. Together with previous studies, this work shows that small molecules from the gut metabolome may have a widespread, significant impact on microbe-microbe interactions established in the gut environment.

First Authors:
Heidi Pauer

Correspondence Authors:
Luis Caetano M Antunes

All Authors:
Heidi Pauer,Felipe Lopes Teixeira,Avery V Robinson,Thiago E Parente,Marília A F De Melo,Leandro A Lobo,Regina M C P Domingues,Emma Allen-Vercoe,Rosana B R Ferreira,Luis Caetano M Antunes

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