张涛+贾慧珏+侯勇:深度剖析中国人的遗传-菌群关联
创作:lzm 审核:mildbreeze 03月11日
  • 纳入632名中国人,通过深度全基因组和宏基因组测序,分析宿主遗传和肠道菌群的关联,并在另外663人的队列中进行验证;
  • 鉴定出与特定细菌分类群显著相关的37个基因座、47个基因和18个拷贝数变异,可共同解释至少20%的肠道菌群组成;
  • 这些遗传信号主要集中在代谢、神经和免疫功能等方面;
  • 鉴定出2个与肠型有关的基因座,解释11%的普氏菌肠型和拟杆菌肠型的差异;
  • 鉴定出33个男性特异和37个女性特异的菌群-宿主遗传关联。
主编推荐语
mildbreeze
人体遗传因素在一定程度上能影响肠道菌群的组成和功能,但相关研究尚未充分开展。Cell Discovery近期发表了深圳华大生命科学研究院张涛、贾慧珏、侯勇与研究团队的成果,纳入近1300名中国人,首次通过深度的全基因组和宏基因组测序,分析了宿主遗传(常见变异、罕见变异和拷贝数变异)与肠道菌群之间的关联,并首次揭示了这些关联中的性别差异。这些发现对于研究宿主遗传因素对肠道菌群的影响及其在健康与疾病中的作用,有重要参考意义。
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Cell Discovery [IF:10.849]

A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases

中国成年人中肠道宏基因组的全基因组关联研究阐明了复杂疾病

10.1038/s41421-020-00239-w

02-09, Article

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The gut microbiome has been established as a key environmental factor to health. Genetic influences on the gut microbiome have been reported, yet, doubts remain as to the significance of genetic associations. Here, we provide shotgun data for whole genome and whole metagenome from a Chinese cohort, identifying no <20% genetic contribution to the gut microbiota. Using common variants-, rare variants-, and copy number variations-based association analyses, we identified abundant signals associated with the gut microbiome especially in metabolic, neurological, and immunological functions. The controversial concept of enterotypes may have a genetic attribute, with the top two loci explaining 11% of the Prevotella–Bacteroides variances. Stratification according to gender led to the identification of differential associations in males and females. Our two-stage metagenome genome-wide association studies on a total of 1295 individuals unequivocally illustrates that neither microbiome nor GWAS studies could overlook one another in our quest for a better understanding of human health and diseases.

First Authors:
Xiaomin Liu

Correspondence Authors:
Yong Hou,Huijue Jia,Tao Zhang

All Authors:
Xiaomin Liu,Shanmei Tang,Huanzi Zhong,Xin Tong,Zhuye Jie,Qiuxia Ding,Dan Wang,Ruidong Guo,Liang Xiao,Xun Xu,Huanming Yang,Jian Wang,Yang Zong,Weibin Liu,Xiao Liu,Yong Zhang,Susanne Brix,Karsten Kristiansen,Yong Hou,Huijue Jia,Tao Zhang

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