菌群结构显著影响膳食纤维的代谢调节功效
创作:this little piggy 审核:周旸 06月05日
  • 基因型相同的无菌小鼠移植两种不同的肠道菌群后,分别给予纤维素、菊粉、果胶和混合膳食纤维饲养4周;
  • 不同膳食纤维饲养的小鼠,其肠道菌群结构具有显著差异;
  • 不同菌群的小鼠食用相同的膳食纤维后,宿主代谢状态不同;
  • 定植有两种菌群的小鼠,其氨基酸和脂质代谢情况、盲肠和血液中代谢物、肝脏基因表达等因素受膳食纤维的影响方式均有差异;
  • 肠道菌群的个体差异,通过菌群-饮食相互作用调节膳食纤维对宿主的代谢调节功效。
主编推荐语
周旸
尽管膳食可发酵纤维的促健康作用得到广泛认可,但是人群研究的数据却难以对膳食可发酵纤维的作用得到一致的结论。Microbiome近期发表一项基于无菌小鼠的研究,阐释了肠道菌群的个体间差异决定了膳食纤维对宿主代谢表型的不同影响,表明了一刀切的膳食纤维补充方法难以在个体间产生一致的效果。该研究对于进一步探索肠道菌群-饮食相互作用对宿主代谢的影响具有重要参考价值,有助于制定个性化的膳食干预措施。
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Microbiome [IF:14.65]

Gut microbiome variation modulates the effects of dietary fiber on host metabolism

肠道菌群差异调控膳食纤维对宿主代谢的影响

10.1186/s40168-021-01061-6

05-20, Article

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BACKGROUND: There is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic microbes and by increasing production of beneficial metabolites in the distal gut. However, human studies have reported variations in the observed benefits among individuals consuming the same fiber. Several factors likely contribute to this variation, including host genetic and gut microbial differences. We hypothesized that gut microbial metabolism of dietary fiber represents an important and differential factor that modulates how dietary fiber impacts the host.
RESULTS: We examined genetically identical gnotobiotic mice harboring two distinct complex gut microbial communities and exposed to four isocaloric diets, each containing different fibers: (i) cellulose, (ii) inulin, (iii) pectin, (iv) a mix of 5 fermentable fibers (assorted fiber). Gut microbiome analysis showed that each transplanted community preserved a core of common taxa across diets that differentiated it from the other community, but there were variations in richness and bacterial taxa abundance within each community among the different diet treatments. Host epigenetic, transcriptional, and metabolomic analyses revealed diet-directed differences between animals colonized with the two communities, including variation in amino acids and lipid pathways that were associated with divergent health outcomes.
CONCLUSION: This study demonstrates that interindividual variation in the gut microbiome is causally linked to differential effects of dietary fiber on host metabolic phenotypes and suggests that a one-fits-all fiber supplementation approach to promote health is unlikely to elicit consistent effects across individuals. Overall, the presented results underscore the importance of microbe-diet interactions on host metabolism and suggest that gut microbes modulate dietary fiber efficacy. Video abstract.

First Authors:
Sofia M Murga-Garrido,Qilin Hong,Tzu-Wen L Cross

Correspondence Authors:
Zheng-Zheng Tang,Federico E Rey

All Authors:
Sofia M Murga-Garrido,Qilin Hong,Tzu-Wen L Cross,Evan R Hutchison,Jessica Han,Sydney P Thomas,Eugenio I Vivas,John Denu,Danilo G Ceschin,Zheng-Zheng Tang,Federico E Rey

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