女性素食者的髋骨骨折风险更高
创作:aluba 审核:aluba 2022年08月21日
  • 纳入26318名35-69岁的英国女性,分为肉食者(每周摄入≥5份肉食)、较少吃肉者(每周摄入<5份肉食)、鱼素食者(只吃鱼不吃肉)、素食者(不吃鱼或肉);
  • 中位随访22.3年期间,共发生822例髋骨骨折;
  • 校正混杂因素后,素食者的髋骨骨折风险显著高于肉食者(HR=1.33),而较少吃肉者或鱼素食者的髋骨骨折风险与肉食者无显著差异;
  • BMI对饮食与髋骨骨折风险的关联无影响。
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aluba
BMC Medicine上发表的一项前瞻性队列研究结果,对超过2.6万名英国女性进行20多年的随访后发现,相比于肉食者,素食者(而非较少吃肉者或鱼素食者)的髋骨骨折风险更高。
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BMC Medicine [IF:11.15]

Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: results from the UK Women’s Cohort Study

肉食者、鱼素食者及素食者的髋骨骨折风险:英国女性队列研究的结果

10.1186/s12916-022-02468-0

2022-08-11, Article

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Background: The risk of hip fracture in women on plant-based diets is unclear. We aimed to investigate the risk of hip fracture in occasional meat-eaters, pescatarians, and vegetarians compared to regular meat-eaters in the UK Women’s Cohort Study and to determine if potential associations between each diet group and hip fracture risk are modified by body mass index (BMI).
Methods: UK women, ages 35–69 years, were classified as regular meat-eaters (≥ 5 servings/week), occasional meat-eaters (< 5 servings/week), pescatarian (ate fish but not meat), or vegetarian (ate neither meat nor fish) based on a validated 217-item food frequency questionnaire completed in 1995–1998. Incident hip fractures were identified via linkage to Hospital Episode Statistics up to March 2019. Cox regression models were used to estimate the associations between each diet group and hip fracture risk over a median follow-up time of 22.3 years.
Results: Amongst 26,318 women, 822 hip fracture cases were observed (556,331 person-years). After adjustment for confounders, vegetarians (HR (95% CI) 1.33 (1.03, 1.71)) but not occasional meat-eaters (1.00 (0.85, 1.18)) or pescatarians (0.97 (0.75, 1.26)) had a greater risk of hip fracture than regular meat-eaters. There was no clear evidence of effect modification by BMI in any diet group (p-interaction = 0.3).
Conclusions: Vegetarian women were at a higher risk of hip fracture compared to regular meat-eaters. Further research is needed to confirm this in men and non-European populations and to identify factors responsible for the observed risk difference. Further research exploring the role of BMI and nutrients abundant in animal-sourced foods is recommended.

First Authors:
Darren C Greenwood,Janet E Cade

Correspondence Authors:
James Webster

All Authors:
James Webster,Darren C Greenwood,Janet E Cade

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