人工合成的新型过硫化物调节肠道菌群
  • 在大肠杆菌的硝基还原酶作用下,供体分子NDP-NAC可释放过硫化物N-乙酰半胱氨酸(NAC-SSH);
  • 与不能释放过硫化物的物质或硫化钠相比,NDP-NAC在小鼠胃中对宿主健康和共生菌群稳态产生了保护作用;
  • NDP-NAC的促健康作用包括上调短链和中链脂肪酸的产生,以及增加有益肠道细菌Turicibacter sanguinis的生长;
  • NDP-NAC还减少了Synergistales科细菌的数量,该科细菌是一种与囊肿、脓肿、牙周病、胃肠道感染相关的条件致病菌。
主编推荐语
周旸
过硫化物(SSH)属于活性硫化物,所释放的硫化氢可作为信号分子、药物前体或者药物佐剂。Angewandte Chemie International Edition近期发表的研究探索了一种新型人工合成过硫化物NDP-NAC对肠道菌群的影响,发现该物质可以对宿主健康和肠道菌群稳态起到保护作用,有望用于菌群干预,值得参考。
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Targeted Delivery of Persulfides to the Gut: Effects on the Microbiome

过硫化物的肠道靶向性递送:对微生物组的影响

10.1002/anie.202014052

01-29, Article

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Persulfides (R−SSH) have been hypothesized as potent redox modulators and signaling compounds. Reported herein is the synthesis, characterization, and in vivo evaluation of a persulfide donor that releases N‐acetyl cysteine persulfide (NAC‐SSH) in response to the prokaryote‐specific enzyme nitroreductase. The donor, termed NDP‐NAC, decomposed in response to E. coli nitroreductase, resulting in release of NAC‐SSH. NDP‐NAC elicited gastroprotective effects in mice that were not observed in animals treated with control compounds incapable of persulfide release or in animals treated with Na2S. NDP‐NAC induced these effects by the upregulation of beneficial small‐ and medium‐chain fatty acids and through increasing growth of Turicibacter sanguinis, a beneficial gut bacterium. It also decreased the populations of Synergistales bacteria, opportunistic pathogens implicated in gastrointestinal infections. This study reveals the possibility of maintaining gut health or treating microbiome‐related diseases by the targeted delivery of reactive sulfur species.

First Authors:
Kearsley M Dillon

Correspondence Authors:
Irving C Allen,John B Matson

All Authors:
Kearsley M Dillon,Holly A Morrison,Chadwick R Powell,Ryan J Carrazzone,Veronica M Ringel-Scaia,Ethan W Winckler,R McAlister Council-Troche,Irving C Allen,John B Matson

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