南京医科大学:试管婴儿的肠道菌群及其对生长发育的影响
创作:戴敏 审核:mildbreeze 2020年08月19日
  • 纳入中国国家出生队列中118位经辅助生殖技术(ART)受孕及91位自然受孕的新生儿,用16S rRNA基因测序检测其出生后前4天的粪便样本,并随访6个月;
  • 与自然受孕的新生儿相比,ART新生儿肠道菌群多样性和拟杆菌门相对丰度显著降低;
  • ART治疗方式(使用阴道栓剂、拮抗剂以及冷冻胚胎移植等)影响新生儿肠道菌群的组成,尤其是拟杆菌门的丰度;
  • 新生儿肠道菌群多样性和拟杆菌门丰度与出生后6个月内(特别是前42天)体重增长率呈负相关。
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mildbreeze
南京医科大学胡志斌和沈洪兵与团队,近期在Gut Microbes发表研究,首次报道了经辅助生殖技术受孕的新生儿肠道菌群的组成特征,及其与出生后6个月内生长率的关系。
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Gut Microbes [IF:9.434]

Alternations of gut microbiota composition in neonates conceived by assisted reproductive technology and its relation to infant growth

经辅助生殖技术受孕的新生儿肠道菌群组成的变化及其与婴儿生长发育的关系

10.1080/19490976.2020.1794466

2020-08-04, Article

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The gut microbiome in newborns may be strongly influenced by their intrinsic host microenviron- mental factors (e.g., the gestational age) and has been linked to their short-term growth and potentially future health. It is yet unclear whether early microbiota composition is significantly different in newborns conceived by assisted reproductive technology (ART) when compared with those who were conceived spontaneously. Additionally, little is known about the effect of gut microbiota composition on weight gain in early infancy. We aimed to characterize the features and the determinants of the gut microbiome in ART newborns and to assess the impact of early microbiota composition on their weight gain in early infancy in mother-infant dyads enrolled in the China National Birth Cohort (CNBC). Among 118 neonates born by ART and 91 neonates born following spontaneous conception, we observed significantly reduced gut microbiota α-diversity and declined Bacteroidetes relative abundance in ART neonates. The microbiota composition of ART neonates was largely driven by specific ART treatments, hinting the importance of fetus intrinsic host microenvironment on the early microbial colonization. Following up these neonates for six months after their births, we observed the effects of gut microbiome composition on infant rapid weight gaining. Collectively, we identified features and determinants of the gut microbiota composition in ART neonates, and provided evidence for the importance of microbiota composi- tion in neonatal growth.

First Authors:
Qun Lu,Yuan Lin,Ting Chen,Hong Lv

Correspondence Authors:
Hongbing Shen,Zhibin Hu

All Authors:
Qun Lu,Yuan Lin,Ting Chen,Hong Lv,Feiyang Diao,Cong Liu,Meijuan Peng,Xiufeng Ling,Hong Li,Yun Wang,Yongyue Wei,Jiangbo Du,Guangfu Jin,Yankai Xia,Hongxia Ma,Xingyin Liu,Hongbing Shen,Zhibin Hu

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