短期摄入较多晚期糖基化终产物,未损害肥胖者糖代谢和血管功能
  • 73名腹型肥胖但其他方面健康的成人被随机分配到精心设计的低或高晚期糖基化终产物(AGEs)饮食组,干预4周;
  • 低和高AGEs饮食组的竣甲基赖氨酸(CML)、羧乙基赖氨酸(CEL)和MG-H1摄入量差异分别为2.7、5.3和3.7倍,与摄入量相一致地,高AGEs饮食组血浆和24h尿液中游离AGEs(CML、CEL和MG-H1)水平高于低AGEs饮食组;
  • 然而,低和高饮食AGEs组之间的胰岛素敏感性、胰岛素分泌或清除、微血管和大血管功能、整体炎症或脂质谱没有差异。
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注册营养师陈彬林
晚期糖基化终产物(AGEs)在体内累积可能导致 2 型糖尿病及其血管并发症的发生发展。 AGEs 广泛存在于食物中,但限制 AGEs 摄入量是否能改善 2 型糖尿病和血管功能障碍的危险因素还存在争议。近期发表于JCI insight的一项随机对照试验表明,4周的低或高AGEs饮食对腹型肥胖个体的生物学影响非常有限。但值得注意的是,高AGEs饮食组尿液CEdG(以往研究认为其具有致突变性)水平增加,因此长期高AGEs是否会引起一些癌症风险增加还需另行探讨。
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JCI insight [IF:9.484]

A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals

4周的高晚期糖基化终产物(AGEs)饮食未损害肥胖个体的糖代谢和血管功能

10.1172/jci.insight.156950

02-08, Article

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BACKGROUND: Accumulation of advanced glycation endproducts (AGEs) may contribute to the pathophysiology of type 2 diabetes and its vascular complications. AGEs are widely present in food, but whether restricting AGE intake improves risk factors for type 2 diabetes and vascular dysfunction is controversial.
RESEARCH DESIGN AND METHODS: Abdominally obese but otherwise healthy individuals were randomly assigned to a specifically designed 4-week diet low or high in AGEs in a double blind parallel-design. Insulin sensitivity, secretion, and clearance were assessed by a combined hyperinsulinemic-euglycemic and hyperglycemic clamp. Micro- and macrovascular function, inflammation, and lipid profile were assessed by state-of-art in vivo measurements and biomarkers. Specific urinary and plasma AGEs Nε-(carboxymethyl)lysine (CML), Nε-(1-carboxyethyl)lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were assessed by mass spectrometry.
RESULTS: In 73 individuals (22 males, mean ± SD age and BMI 52 y ± 14, 30.6 kg/m2 ± 4.0), intake of CML, CEL, and MG-H1 differed 2.7, 5.3, and 3.7-fold between the low and high AGE diets, which led to corresponding changes of these AGEs in urine and plasma. Despite this, there was no difference in insulin sensitivity, secretion, or clearance, micro- and macrovascular function, overall inflammation, or lipid profile between the low and high dietary AGE groups (all p for treatment effects > 0.05).
CONCLUSIONS: This comprehensive RCT demonstrates very limited biological consequences of a 4-week diet low or high in AGEs in abdominally obese individuals.
TRIAL REGISTRATION: clinicaltrials.gov: NCT03866343, trialregister.nl: NTR7594.
FUNDING: Diabetesfonds and ZonMw.

First Authors:
Armand M A Linkens

Correspondence Authors:
Casper Schalkwijk

All Authors:
Armand M A Linkens,Alfons J Houben,Petra M Niessen,Nicole Wijckmans,Erica de Goei,Mathias Dg Van den Eynde,Jean L J M Scheijen,Marjo Waarenburg,Andrea Mari,Tos Tjm Berendschot,Lukas Streese,Henner Hanssen,Martien Cjm van Dongen,Christel van Gool,Coen DA Stehouwer,Simone Jpm Eussen,Casper Schalkwijk

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