Cell子刊:超氧化物歧化酶,孕期健康的关键信号分子
创作:尹小甜 审核:Epi汪 04月02日
  • 动物模型分为超氧化物歧化酶(SOD3)敲除和对照组,并分为运动组和静止组,同时补充不同浓度的维生素D;
  • 无论在小鼠还是人体中,经常运动的孕妇血清和胎盘中SOD的表达均上调;
  • 孕期补充维生素D可通过促进胎盘SOD3表达而实现健康效应;
  • SOD3激活胎儿后代肝脏中的AMPK/TET信号轴,导致葡萄糖代谢基因启动子处DNA去甲基化,从而增强肝功能,提高糖耐量;
  • 或许血清中SOD3浓度可以作为妊娠期运动训练强度的一个生物学指标。
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Epi汪
发表在《Cell Metabolism》上的研究发现,孕期运动量较大的女性其血清中SOD3的浓度增加,其可以增加后代的肝功能和糖耐量水平,或许是预防肥胖等慢性病的关键信号分子。
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Cell Metabolism [IF:27.287]

Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

胎盘超氧化物歧化酶3介导母亲运动对后代健康的益处

10.1016/j.cmet.2021.03.004

03-25, Article

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Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, adding to the ever-increasing prevalence of these diseases. In contrast, we find that maternal exercise improves the metabolic health of offspring, and here, we demonstrate that this occurs through a vitamin D receptor-mediated increase in placental superoxide dismutase 3 (SOD3) expression and secretion. SOD3 activates an AMPK/TET signaling axis in fetal offspring liver, resulting in DNA demethylation at the promoters of glucose metabolic genes, enhancing liver function, and improving glucose tolerance. In humans, SOD3 is upregulated in serum and placenta from physically active pregnant women. The discovery of maternal exercise-induced cross talk between placenta-derived SOD3 and offspring liver provides a central mechanism for improved offspring metabolic health. These findings may lead to novel therapeutic approaches to limit the transmission of metabolic disease to the next generation.

First Authors:
Joji Kusuyama

Correspondence Authors:
Joji Kusuyama,Laurie J Goodyear

All Authors:
Joji Kusuyama,Ana Barbara Alves-Wagner,Royce H Conlin,Nathan S Makarewicz,Brent G Albertson,Noah B Prince,Shio Kobayashi,Chisayo Kozuka,Magnus Møller,Mette Bjerre,Jens Fuglsang,Emily Miele,Roeland JW Middelbeek,Yang Xiudong,Yang Xia,Léa Garneau,Jayonta Bhattacharjee,Céline Aguer,Mary Elizabeth Patti,Michael F Hirshman,Niels Jessen,Toshihisa Hatta,Per Glud Ovesen,Kristi B Adamo,Eva Nozik-Grayck,Laurie J Goodyear

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