创作:Evan 审核:大月半 2016年07月19日
  • 微生物,尤其是细菌,在大肠癌发生过程中的作用是可预见的;
  • 越来越多可用的微生物宏组学数据,使得我们能分析微生物和微生物群落在大肠癌中扮演的角色;
  • 本综述讨论近年来微生物对结直肠癌贡献的见解,并探讨微生物如何成为癌症的诱因;
  • 列出可能引发结肠癌的物种以及目前对它们的认识,并讨论与胆汁酸、外源性物质和饮食有关的微生物代谢产物,更进一步探索结肠癌的病因及其治疗方法。
#Cell Press Nucleus微生物组专辑# #菌群与肿瘤文献集#

Microbes, microbiota, and colon cancer



2014-03-17, Review

Abstract & Authors:展开

Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate a role for microbes, particularly bacteria, in colorectal carcinogenesis. The increasing accessibility of microbial meta'omics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. In this review, we will discuss recent insights into contributions of the microbiota to CRC and explore conceptual frameworks for evaluating the role of microbes in cancer causation. We also highlight new findings on candidate CRC-potentiating species and current knowledge gaps. Finally, we explore the roles of microbial metabolism as it relates to bile acids, xenobiotics, and diet in the etiology and therapeutics of CRC.

First Authors:
Cynthia L Sears

Correspondence Authors:
Cynthia L Sears

All Authors:
Cynthia L Sears,Wendy S Garrett