吃过多红肉及加工肉,或增加多种癌症风险
创作:aluba 审核:aluba 09月06日
  • 纳入148项前瞻性研究进行荟萃分析;
  • 红肉摄入与更高的乳腺癌(RR=1.09)、子宫内膜癌(RR=1.25)、结直肠癌(RR=1.10)、结肠癌(RR=1.17)、直肠癌(RR=1.22)、肺癌(RR=1.26)及肝细胞癌(RR=1.22)风险相关;
  • 加工肉类摄入与更高的乳腺癌(RR=1.06)、结直肠癌(RR=1.18)、结肠癌(RR=1.21)、直肠癌(RR=1.22)及肺癌(RR=1.12)风险相关;
  • 总红肉+加工肉类摄入与更高的结直肠癌、结肠癌、直肠癌、肺癌及肾细胞癌风险显著相关。
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aluba
European Journal of Epidemiology上发表的一项荟萃分析结果,总结了148项前瞻性研究的数据后发现,红肉和/或加工肉类摄入与多种癌症的风险增加显著相关,包括乳腺癌、结直肠癌、肺癌等。
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Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies

红肉及加工肉类摄入与癌症发病率:对前瞻性研究的系统性综述与荟萃分析

10.1007/s10654-021-00741-9

08-29, Article

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Red meat and processed meat consumption has been hypothesized to increase risk of cancer, but the evidence is inconsistent. We performed a systematic review and meta-analysis of prospective studies to summarize the evidence of associations between consumption of red meat (unprocessed), processed meat, and total red and processed meat with the incidence of various cancer types. We searched in MEDLINE and EMBASE databases through December 2020. Using a random-effect meta-analysis, we calculated the pooled relative risk (RR) and 95% confidence intervals (CI) of the highest versus the lowest category of red meat, processed meat, and total red and processed meat consumption in relation to incidence of various cancers. We identified 148 published articles. Red meat consumption was significantly associated with greater risk of breast cancer (RR = 1.09; 95% CI = 1.03-1.15), endometrial cancer (RR = 1.25; 95% CI = 1.01-1.56), colorectal cancer (RR = 1.10; 95% CI = 1.03-1.17), colon cancer (RR = 1.17; 95% CI = 1.09-1.25), rectal cancer (RR = 1.22; 95% CI = 1.01-1.46), lung cancer (RR = 1.26; 95% CI = 1.09-1.44), and hepatocellular carcinoma (RR = 1.22; 95% CI = 1.01-1.46). Processed meat consumption was significantly associated with a 6% greater breast cancer risk, an 18% greater colorectal cancer risk, a 21% greater colon cancer risk, a 22% greater rectal cancer risk, and a 12% greater lung cancer risk. Total red and processed meat consumption was significantly associated with greater risk of colorectal cancer (RR = 1.17; 95% CI = 1.08-1.26), colon cancer (RR = 1.21; 95% CI = 1.09-1.34), rectal cancer (RR = 1.26; 95% CI = 1.09-1.45), lung cancer (RR = 1.20; 95% CI = 1.09-1.33), and renal cell cancer (RR = 1.19; 95% CI = 1.04-1.37). This comprehensive systematic review and meta-analysis study showed that high red meat intake was positively associated with risk of breast cancer, endometrial cancer, colorectal cancer, colon cancer, rectal cancer, lung cancer, and hepatocellular carcinoma, and high processed meat intake was positively associated with risk of breast, colorectal, colon, rectal, and lung cancers. Higher risk of colorectal, colon, rectal, lung, and renal cell cancers were also observed with high total red and processed meat consumption.

First Authors:
Maryam S Farvid

Correspondence Authors:
Maryam S Farvid

All Authors:
Maryam S Farvid,Elkhansa Sidahmed,Nicholas D Spence,Kingsly Mante Angua,Bernard A Rosner,Junaidah B Barnett

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