Nature子刊:增加全谷物和膳食纤维,降低肝癌和慢性肝病死亡风险
  • 本研究纳入485,717名美国参与者,女性占比40.2%,基线均龄61.5岁,在平均随访15.5年中,共确定940例肝癌病例和993例慢性肝病死亡病例;
  • 全谷物摄入量最高五分位的参与者患肝癌的风险降低了22%,总体慢性肝病的死亡率降低了56%;
  • 总膳食纤维摄入量最高五分位的参与者患肝癌的风险降低了31%,总慢性肝病死亡率降低了63%,在此关联中的膳食纤维主要来自蔬菜、豆类和谷物而非水果,可能是水果的高果糖抵消了纤维的有益作用。
主编推荐语
临床营养陈彬林
近期哈佛大学陈曾熙公共卫生学院营养系的Xuehong Zhang在Nature Communications发表的一项研究表明摄入较多的全谷物和膳食纤维会降低肝癌和慢性肝病的死亡率,其中在此关联中的膳食纤维主要是来自蔬菜、豆类和谷物的纤维。《中国居民膳食指南2016》推荐普通成人每天吃50克~150克全谷物和杂豆类。
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Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality

全谷物和膳食纤维的高摄入量与较低的肝癌风险和慢性肝病死亡率有关

10.1038/s41467-021-26448-9

2021-11-04, Article

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The relationship between dietary factors and liver disease remains poorly understood. This study evaluated the associations of whole grain and dietary fiber intake with liver cancer risk and chronic liver disease mortality. The National Institutes of Health–American Association of Retired Persons Diet and Health Study cohort recruited 485, 717 retired U.S. participants in 1995–1996. Follow-up through 2011 identified 940 incident liver cancer cases and 993 deaths from chronic liver disease. Compared with the lowest, the highest quintile of whole grain intake was associated with lower liver cancer risk (Hazard ratio [HR]Q5 vs. Q1 = 0.78, 95% confidence interval [CI]: 0.63–0.96) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.44, 95% CI: 0.35–0.55) in multivariable Cox models. Dietary fiber was also associated with lower liver cancer risk (HRQ5 vs. Q1 = 0.69, 95% CI: 0.53–0.90) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.37, 95% CI: 0.29–0.48). Fiber from vegetables, beans and grains showed potential protective effect. Here, we show that higher intake of whole grain and dietary fiber are associated with lower risk of liver cancer and liver disease mortality.

First Authors:
Xing Liu

Correspondence Authors:
Xuehong Zhang

All Authors:
Xing Liu,Wanshui Yang,Jessica L Petrick,Linda M Liao,Weibing Wang,Na He,Peter T Campbell,Zuo-Feng Zhang,Edward Giovannucci,Katherine A McGlynn,Xuehong Zhang

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