蔺蓉团队:可无创获取肠道生物信息的新型胶囊内镜
创作:徐硕 审核:mildbreeze 2021年02月01日
  • 开发一种新型磁控采样胶囊内窥镜(MSCE),用其采集模型猪的肠内容物,分析微生物组和代谢组,并与手术采样的分析结果比对验证;
  • MSCE能通过可视化方式,方便、无创、准确地获取不同区域(空肠、回肠)和不同疾病状态下(健康vs抗生素腹泻)的肠内容物,成功率很高,且取样后密封良好无污染;
  • 与手术采样对比表明,使用MSCE取样可以准确得到疾病相关的肠道菌群和代谢物丰度数据;
  • MSCE或能在疾病的预防、诊断和治疗中发挥重要作用。
主编推荐语
mildbreeze
获取肠道菌群和代谢物信息的方法,目前主要包括氢呼气试验、粪便菌群检测和有创的内镜取样,这些方法都存在一些局限性。华中科技大学协和医院蔺蓉团队近期在Gut发表一项重要研究,报道了一种新型的磁控采样胶囊内镜(MSCE),能以可视化的方式,无创、准确地获取胃肠道的生物信息,包括采集肠道内容物用于菌群和代谢组分析等,该方法有望用于临床的疾病预防、诊断和个体化治疗以及肠道相关研究,值得专业人士阅读学习。
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Gut [IF:31.793]

Novel scheme for non-invasive gut bioinformation acquisition with a magnetically controlled sampling capsule endoscope

基于磁控取样胶囊内窥镜的无创肠道生物信息获取新方案

10.1136/gutjnl-2020-322465

2021-01-15, Article

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Objective : Intestinal flora and metabolites are associated with multiple systemic diseases. Current approaches for acquiring information regarding microbiota/metabolites have limitations. We aimed to develop a precise magnetically controlled sampling capsule endoscope (MSCE) for the convenient, non-invasive and accurate acquisition of digestive bioinformation for disease diagnosis and evaluation.
Design : The MSCE and surgery were both used for sampling both jejunal and ileal GI content in the control and antibiotic-induced diarrhoea groups. The GI content was then used for microbiome profiling and metabolomics profiling.
Results: Compared with surgery, our data showed that the MSCE precisely acquired data regarding the intestinal flora and metabolites, which was effectively differentiated in different intestinal regions and disease models. Using MSCE, we detected a dramatic decrease in the abundance of Bacteroidetes, Patescibacteria and Actinobacteria and hippuric acid levels, as well as an increase in the abundance of Escherichia–Shigella and the 2-pyrrolidinone levels were detected in the antibiotic-induced diarrhoea model by MSCE. MSCE-mediated sampling revealed specific gut microbiota/metabolites including Enterococcus, Lachnospiraceae, acetyl-L-carnitine and succinic acid, which are related to metabolic diseases, cancers and nervous system disorders. Additionally, the MSCE exhibited good sealing characteristics with no contamination after sampling.
Conclusions : We present a newly developed MSCE that can non-invasively and accurately acquire intestinal bioinformation via direct visualization under magnetic control, which may further aid in disease prevention, diagnosis, prognosis and treatment.

First Authors:
Zhen Ding,Weijun Wang,Kun Zhang

Correspondence Authors:
Rong Lin

All Authors:
Zhen Ding,Weijun Wang,Kun Zhang,Fanhua Ming,Tianyi Yangdai,Tao Xu,Huiying Shi,Yuhui Bao,Hailing Yao,Hangyu Peng,Chaoqun Han,Weiwei Jiang,Jun Liu,Xiaohua Hou,Rong Lin

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