任志刚+余祖江:新冠康复者愈后1年的微生物组和代谢组特征
创作:梁然 审核:Johnson 07月26日
  • 对35名COVID-19(新冠)确诊患者愈后以及愈后1年进行口腔、粪便微生物组以及血浆代谢组检测,对照为160名健康人;
  • 愈后1年,口腔和肠道微生物组多样性有所恢复,其中口腔菌群恢复速度较快,肠道菌群中产丁酸细菌和双歧菌属丰度上升、产脂多糖细菌丰度下降;
  • 血浆中与新冠的炎症因子风暴相关的1-磷酸鞘氨醇显著增加;
  • 使用愈后三组数据建立新冠病人愈后1年中和抗体无创预测模型,效果良好,其中新冠病人愈后血浆代谢组预测效果最好。
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这是发表在Military Medical Research上的一份工作,由郑大一附院的余祖江、任志刚及其团队完成。他们收集了35名新冠患者愈后及随访1年后的口腔、粪便及血浆,进行组学研究。其中微生物组表现出恢复趋势,但未完全恢复到健康对照水平,有趣的是口腔菌群恢复速度较肠道菌群快。另外,血浆代谢组展示出1-磷酸鞘氨醇显著增加。使用愈后三组数据建立的新冠病人愈后1年中和抗体无创预测模型效果良好,血浆代谢组效果最好。另外,关联分析揭示出微生物组、代谢组与愈后恢复程度密切相关。这份研究也鉴定出一系列新冠愈后恢复菌群标志物,助力新冠康复者后续健康保障。
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Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up

随访1年后COVID-19患者的口腔和肠道微生物组和血浆代谢组学的特征分析

10.1186/s40779-022-00387-y

06-17, Article

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Background: Due to the outbreak and rapid spread of coronavirus disease 2019 (COVID-19), more than 160 million patients have become convalescents worldwide to date. Significant alterations have occurred in the gut and oral microbiome and metabonomics of patients with COVID-19. However, it is unknown whether their characteristics return to normal after the 1-year recovery.
Methods: We recruited 35 confirmed patients to provide specimens at discharge and one year later, as well as 160 healthy controls. A total of 497 samples were prospectively collected, including 219 tongue-coating, 129 stool and 149 plasma samples. Tongue-coating and stool samples were subjected to 16S rRNA sequencing, and plasma samples were subjected to untargeted metabolomics testing.
Results: The oral and gut microbiome and metabolomics characteristics of the 1-year convalescents were restored to a large extent but did not completely return to normal. In the recovery process, the microbial diversity gradually increased. Butyric acid-producing microbes and Bifidobacterium gradually increased, whereas lipopolysaccharide-producing microbes gradually decreased. In addition, sphingosine-1-phosphate, which is closely related to the inflammatory factor storm of COVID-19, increased significantly during the recovery process. Moreover, the predictive models established based on the microbiome and metabolites of patients at the time of discharge reached high efficacy in predicting their neutralizing antibody levels one year later.
Conclusions: This study is the first to characterize the oral and gut microbiome and metabonomics in 1-year convalescents of COVID-19. The key microbiome and metabolites in the process of recovery were identified, and provided new treatment ideas for accelerating recovery. And the predictive models based on the microbiome and metabolomics afford new insights for predicting the recovery situation which benefited affected individuals and healthcare.

First Authors:
Guangying Cui,Benchen Rao,Zhao-Hai Zeng,Xuemei Wang,Tong Ren

Correspondence Authors:
Zhigang Ren,Zujiang Yu

All Authors:
Guangying Cui,Benchen Rao,Zhao-Hai Zeng,Xuemei Wang,Tong Ren,Hai-Yu Wang,Hong Luo,Hong-Yan Ren,Chao Liu,Su-Ying Ding,Jun-Jie Tan,Zhen-Guo Liu,Ya-Wen Zou,Zhigang Ren,Zujiang Yu

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