清华程功团队:调节昆虫肠道内稳态的信号通路
  • 证明在埃及伊蚊和黑腹果蝇的肠道中,双氧化酶(Duox)调节通路有助于维持稳态:
  • 肠膜相关蛋白Mesh通过抑制蛋白(Arrestin)介导的MAPK JNK/ERK磷酸化级联反应,调节Duox的表达,以此在控制肠道细菌增殖中发挥重要作用;
  • 在埃及伊蚊进食血液后,Mesh和Duox的表达迅速增加,且都与肠道细菌菌群有关;
  • 清除Mesh会终止Duox的诱导,导致肠道微生物组负荷的增加。
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蓝灿辉 | 热心肠先生
来自清华大学程功团队的昆虫肠道菌群信号通路研究,值得读一读。
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Nature Microbiology [IF:17.745]

A Mesh–Duox pathway regulates homeostasis in the insect gut

Mesh蛋白–双氧化酶通路调节昆虫肠道内稳态

10.1038/nmicrobiol.2017.20

2017-03-01, Article

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The metazoan gut harbours complex communities of commensal and symbiotic bacterial microorganisms. The quantity and quality of these microorganisms fluctuate dynamically in response to physiological changes. The mechanisms that hosts have developed to respond to and manage such dynamic changes and maintain homeostasis remain largely unknown. Here, we identify a dual oxidase (Duox)-regulating pathway that contributes to maintaining homeostasis in the gut of both Aedes aegypti and Drosophila melanogaster. We show that a gut-membrane-associated protein, named Mesh, plays an important role in controlling the proliferation of gut bacteria by regulating Duox expression through an Arrestin-mediated MAPK JNK/ERK phosphorylation cascade. Expression of both Mesh and Duox is correlated with the gut bacterial microbiome, which, in mosquitoes, increases dramatically soon after a blood meal. Ablation of Mesh abolishes Duox induction, leading to an increase of the gut microbiome load. Our study reveals that the Mesh-mediated signalling pathway is a central homeostatic mechanism of the insect gut.

First Authors:
Xiaoping Xiao,Lijuan Yang,Xiaojing Pang

Correspondence Authors:
Guanjun Gao,Gong Cheng

All Authors:
Xiaoping Xiao,Lijuan Yang,Xiaojing Pang,Rudian Zhang,Yibin Zhu,Penghua Wang,Guanjun Gao,Gong Cheng

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