江南大学:不同饮食模式如何影响衰老(综述)
创作:赵静 审核:EADGBE 07月31日
  • 冲绳饮食、地中海饮食、DASH饮食,以及温和的热量限制和间歇性禁食是通过调节营养感知途径、肠道菌群、代谢和免疫来抗衰老的可靠饮食模式,生酮饮食的抗衰老作用存在争议;
  • 不同的饮食模式和补充剂(天然热量限制模拟物、senolytics、益生菌、维生素和必需矿物质等)的组合可能会产生叠加效应;
  • 个体的衰老速度和饮食反应高度可变,营养基因组学在个性化饮食策略中起着重要作用;
  • 确定准确的衰老生物标志物对精确的饮食干预至关重要。
主编推荐语
EADGBE
衰老是生物体不可避免的物理和生理功能的退化,包括原发性衰老(primary aging)和继发性衰老(secondary aging),前者是衰老的固有过程,后者可以受到各种外在因素如饮食、药物和疾病的影响。因此,不同个体的衰老速度差异很大。饮食干预是一种安全、广谱、低成本的延缓衰老预防策略。江南大学食品学院范柳萍和于雷雷等人在Food Research International上发表一项综述,对各种饮食模式和补充剂的抗衰老效果进行了比较,分析了它们的作用机制和联合使用,并提出了实现个性化饮食策略以减缓衰老的未来研究方向。
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Dietary strategies with anti-aging potential: Dietary patterns and supplements

具有抗衰老潜力的饮食策略:膳食模式和补充剂

10.1016/j.foodres.2022.111501

06-13, Review

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Dietary intervention is a safe, broad-spectrum, and low-cost preventive strategy for slow aging. The Okinawan, Mediterranean, and Dietary approaches to stop hypertension (DASH) diets, as well as caloric restriction (CR) and intermittent fasting (IF), are classic and reliable dietary patterns that slow aging by regulating nutrient-sensing pathways, gut microbiota, metabolism, and immunity. Moreover, the proportion of the three macronutrients (carbohydrate, protein and fat) is also vital for slowing aging, but the debates about the appropriate proportion, especially the ratio of carbohydrates and proteins, remain unknown. Strict and lifelong adherence to these regimens is difficult, thereby promoting the emergence of various dietary supplements, including natural CR mimics, probiotics, natural senolytics, vitamins and essential minerals. Combinations of different dietary patterns and supplements with distinct pathways may have additive effects. Individuals’ aging speed and dietary response are highly variable, thus highlighting the need for precise anti-aging dietary intervention. Nutrigenomics plays an important role in personalized dietary strategies. Therefore, this review critically compares the anti-aging effects of various dietary patterns and supplements, analyzes their mechanisms and combined use, and proposes future research directions to achieve personalized dietary strategies for slowing aging.

First Authors:
Hui Duan

Correspondence Authors:
Leilei Yu,Liuping Fan

All Authors:
Hui Duan,Jiani Pan,Min Guo,Jinwei Li,Leilei Yu,Liuping Fan

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