中山大学附属肿瘤医院：ctDNA或可预测胃癌免疫治疗效果
- ①纳入46名接受PD-1单抗治疗的胃癌患者，对ctDNA进行NGS测序分析；
- ②ctDNA中的最大体细胞突变等位基因频率（maxVAF）降低超过25%的患者，有着更长的中位PFS（7.3个月 vs. 3.6个月）及更高的应答率（53.5% vs. 13.3%）；
- ③无法检测到ctDNA的患者的中位PFS为7.4个月，显著高于可检测到ctDNA的患者的4.9个月；
- ④基线ctDNA中的TGFBR2、RHOA及PREX2基因上存在特定突变的患者的中位PFS显著短于无突变患者。
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中山大学附属肿瘤医院的张东生团队与徐瑞华团队在Molecular Cancer上发表的一项最新研究，在46名接受PD-1单抗治疗的胃癌患者中发现，循环肿瘤DNA（ctDNA）的数量、突变频率及特定基因的突变状态可能影响患者的无进展生存期（PFS）及应答率，另外，ctDNA中特定基因的突变可能影响免疫相关不良事件发生率。
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The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors
循环肿瘤DNA谱对接受免疫检查点抑制剂治疗的胃癌患者的预测作用
10.1186/s12943-020-01274-7
2020-10-30, Article
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A more common and noninvasive predicting biomarker for programmed cell death 1 (PD-1) antibody remains to be explored. We assessed 46 patients with advanced gastric cancer who received PD-1 antibody immunotherapy and 425-genes next-generation sequencing (NGS) testing. Patients who had a > 25% decline in maximal somatic variant allelic frequency (maxVAF) had a longer progression free survival (PFS) and higher response rate than those who did not (7.3 months vs 3.6 months, p = 0.0011; 53.3% vs 13.3%, p = 0.06). The median PFS of patients with undetectable and detectable post-treatment circulating tumor DNA (ctDNA) was 7.4 months vs. 4.9 months (p = 0.025). Mutation status of TGFBR2, RHOA, and PREX2 in baseline ctDNA influenced the PFS of immunotherapy (p < 0.05). Patients with alterations in CEBPA, FGFR4, MET or KMT2B (p = 0.09) gene had greater likelihood of immune-related adverse events (irAEs). ctDNA can serve as a potential biomarker of the response to immunotherapy in advanced gastric cancers, and its potential role in predicting irAEs worth further exploration.
First Authors:
Ying Jin,Dong-Liang Chen,Feng Wang
Correspondence Authors:
Rui-Hua Xu,Dongsheng Zhang
All Authors:
Ying Jin,Dong-Liang Chen,Feng Wang,Chao-pin Yang,Xu-Xian Chen,Jin-qi You,Jin-Sheng Huang,Yang Shao,Dong-Qin Zhu,Yu-Ming Ouyang,Huiyan Luo,Zhiqiang Wang,Feng-Hua Wang,Yu-Hong Li,Rui-Hua Xu,Dongsheng Zhang
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