国内团队:菌群-肠-脑轴的甘油磷脂代谢紊乱,或参与抑郁症发病
创作:楸楸 审核:mildbreeze 2020年05月14日
  • 选用雌性食蟹猕猴建立抑郁模型,表征其肠道菌群的组成和功能以及肠脑代谢特征;
  • 与对照组相比,抑郁样(DL)猕猴的菌群组成发生改变(主要是厚壁菌门);
  • 通过加权基因共表达网络分析(WGCNA),鉴定出DL猕猴菌群-肠-脑轴中发生改变的3个微生物模块和4个代谢模块,主要涉及脂肪酰基、鞘脂和甘油磷脂代谢;
  • 大脑海马的甘油磷脂代谢紊乱,是DL猕猴的一个显著特征;
  • 肠道菌群可能通过调节外周和中枢的甘油磷脂代谢,参与抑郁行为的发生。
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mildbreeze
越来越多的证据表明,菌群-肠-脑轴的变化与抑郁症发病存在关联,但背后的生物学机制尚不清楚。重庆医科大学第一附属医院谢鹏团队近期在《Molecular Psychiatry》发表合作研究,对食蟹猴抑郁模型的肠道菌群和肠脑轴代谢特征进行了深入分析,表明菌群-肠-脑轴中的甘油磷脂代谢紊乱可能在抑郁症中有重要作用。
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The gut microbiome modulates gut–brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression

在非人类灵长类动物抑郁模型中,肠道菌群以区域特异性方式调节肠-脑轴甘油磷脂代谢

10.1038/s41380-020-0744-2

2020-04-20, Article

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Emerging research demonstrates that microbiota-gut–brain (MGB) axis changes are associated with depression onset, but the mechanisms underlying this observation remain largely unknown. The gut microbiome of nonhuman primates is highly similar to that of humans, and some subordinate monkeys naturally display depressive-like behaviors, making them an ideal model for studying these phenomena. Here, we characterized microbial composition and function, and gut–brain metabolic signatures, in female cynomolgus macaque (Macaca fascicularis) displaying naturally occurring depressive-like behaviors. We found that both microbial and metabolic signatures of depressive-like macaques were significantly different from those of controls. The depressive-like monkeys had characteristic disturbances of the phylum Firmicutes. In addition, the depressive-like macaques were characterized by changes in three microbial and four metabolic weighted gene correlation network analysis (WGCNA) clusters of the MGB axis, which were consistently enriched in fatty acyl, sphingolipid, and glycerophospholipid metabolism. These microbial and metabolic modules were significantly correlated with various depressive-like behaviors, thus reinforcing MGB axis perturbations as potential mediators of depression onset. These differential brain metabolites were mainly mapped into the hippocampal glycerophospholipid metabolism in a region- specific manner. Together, these findings provide new microbial and metabolic frameworks for understanding the MGB axisʼ role in depression, and suggesting that the gut microbiome may participate in the onset of depressive-like behaviors by modulating peripheral and central glycerophospholipid metabolism.

First Authors:
Peng Zheng

Correspondence Authors:
Julio Licinio,Peng Xie

All Authors:
Peng Zheng,Jing Wu,Hanping Zhang,Seth W Perry,Bangmin Yin,Xunmin Tan,Tingjia Chai,Weiwei Liang,Yu Huang,Yifan Li,Jiajia Duan,Ma-Li Wong,Julio Licinio,Peng Xie

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