浙江大学:母猪摄入发酵饮食,可抑制仔猪的肠道炎症
创作:一只赵崽儿呀 审核:aluba 05月12日
  • MFD提高母猪的摄食量及产乳量,改变肠道菌群和乳汁代谢组,提升仔猪的体重增加,降低仔猪的腹泻发病率;
  • MFD加快新生猪断奶后的肠道菌群成熟,增加肠道乳杆菌属的丰度,增强菌群的氨基酸相关酶和葡萄糖代谢功能;
  • MFD降低后代的结肠炎易感性,移植MFD母猪粪菌可缓解LPS引起的幼鼠肠道乳杆菌属减少和肠道屏障损伤;
  • 母乳L-谷氨酰胺(GLN)和肠道罗伊氏乳杆菌(LR)通过抑制p38及JNK磷酸化和Caspase3活化,介导MFD的结肠炎症保护作用。
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浙江大学的汪以真团队在Gut Microbes上发表的一项最新研究结果,母猪摄入发酵饮食(MFD)可通过富集母猪肠道菌群中的乳杆菌属,并增加乳汁中的L-谷氨酰胺,从而加快后代仔猪的肠道菌群成熟,以促进后代仔猪的体重增加,并降低腹泻发病率。将MFD母猪的粪菌移植给幼鼠,可缓解LPS诱导的肠道屏障损伤。
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Gut Microbes [IF:9.434]

Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota

母猪摄入发酵饮食可通过调节肠道菌群,以保护后代免受肠道炎症

10.1080/19490976.2022.2057779

05-04, Article

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The neonatal intestinal tract is immature and can be easily infected by pathogens causing inflammation. Maternal diet manipulation is a promising nutritional strategy to enhance the gut health of offspring. A fermented diet is a gut microbiota targeting diet containing live probiotics and their metabolites, which benefit the gut and overall health host. However, it remains unclear how a maternal fermented diet (MFD) affects neonatal intestinal inflammation. Here, in vivo and in vitro models together with multi-omics analysis were applied to investigate the impacts and the underlying mechanism through which an MFD prevents from gut inflammation in neonates. An MFD remarkably improved the performance of both sows and piglets and significantly altered the gut microbiome and milk metabolome of sows. In addition, the MFD significantly accelerated the maturation of the gut microbiota of neonates and increased the abundance of gut Lactobacillus and the microbial functions of amino acid-related enzymes and glucose metabolism on the weaning day. Notably, the MFD reduced susceptibility to colonic inflammation in offspring. The fecal microbiota of sows was then transplanted into mouse dams and it was found that the mouse dams and pups in the MFD group alleviated the LPS-induced decrease in gut Lactobacillus abundance and barrier injury. Milk L-glutamine (GLN) and gut Lactobacillus reuteri (LR) were found as two of the main MFD-induced sow effectors that contributed to the gut health of piglets. The properties of LR and GLN in modulating gut microbiota and alleviating colonic inflammation by inhibiting the phosphorylation of p38 and JNK and activation of Caspase 3 were further verified. These findings provide the first data revealing that an MFD drives neonate gut microbiota development and ameliorates the colonic inflammation by regulating the gut microbiota. This fundamental evidence might provide references for modulating maternal nutrition to enhance early-life gut health and prevent gut inflammation.

First Authors:
Cheng Wang

Correspondence Authors:
Yizhen Wang

All Authors:
Cheng Wang,Siyu Wei,Bojing Liu,Fengqin Wang,Zeqing Lu,Mingliang Jin,Yizhen Wang

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