宁波大学:卡拉胶伤菌群、坏屏障,或恶化结肠炎
创作:aluba 审核:aluba 2021年11月02日
  • 在鼠柠檬酸杆菌诱导的感染性结肠炎小鼠模型中,λ-卡拉胶可恶化肠道炎症及临床症状的严重程度;
  • 高膳食λ-卡拉胶摄入可改变小鼠的结肠菌群组成,从而导致结肠黏液层降解,增加粪便LPS水平,并降低粪便短链脂肪酸水平;
  • 将摄入高膳食λ-卡拉胶的小鼠的粪菌移植给无菌小鼠,可重现结肠黏液层受损、粪便LPS水平增加及粪便短链脂肪酸水平降低的表型;
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aluba
卡拉胶是一种常见的食品添加剂。宁波大学的王峰、陈海敏与团队在Pharmacological Research上发表的一项最新研究结果,发现λ-卡拉胶可通过诱导肠道菌群失调及肠道屏障受损,从而恶化鼠柠檬酸杆菌诱导的小鼠感染性结肠炎。
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λ-carrageenan exacerbates Citrobacter rodentium-induced infectious colitis in mice by targeting gut microbiota and intestinal barrier integrity

λ-卡拉胶通过靶向肠道菌群及肠道屏障完整性,以恶化鼠柠檬酸杆菌诱导的小鼠感染性结肠炎

10.1016/j.phrs.2021.105940

2021-10-16, Article

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For nearly half a century, the scientific community has been unable to agree upon the safety profile of carrageenan (CGN), a ubiquitous food additive. Little is known about the mechanisms by which consumption of CGN aggravates the etiopathogenesis of murine colitis. However, analyses of gut microbiota and intestinal barrier integrity have provided a breakthrough in explaining the synergistic effect of CGN upon colitis. In Citrobacter rodentium-induced infectious murine colitis, inflammation and the clinical severity of gut tissue were aggravated in the presence of λ-CGN. Using fecal transplantation and germ-free mice experiments, we evaluated the role of intestinal microbiota on the pro-inflammatory effect of λ-CGN. Mice with high dietary λ-CGN consumption showed altered colonic microbiota composition that resulted in degradation of the colonic mucus layer, a raised fecal LPS level, and a decrease in the presence of bacterially derived short-chain fatty acids (SCFAs). Mucus layer defects and altered fecal LPS and SCFA levels could be reproduced in germ-free mice by fecal transplantation from CGN-H-fed mice, but not from germ-free CGN-H-fed mice. Our results confirm that λ-CGN may create an environment that favors inflammation by altering gut microbiota composition and gut bacterial metabolism. The present study provides evidence that the "gut microbiota-barrier axis" could be an alternative target for ameliorating the colitis promoting effect of λ-CGN.

First Authors:
Wei Wu,Dongsheng Zhou

Correspondence Authors:
Haimin Chen,Feng Wang

All Authors:
Wei Wu,Dongsheng Zhou,Rongrong Xuan,Jiawei Zhou,Jingwangwei Liu,Juanjuan Chen,Hui Han,Tingting Niu,Xingxing Li,Haimin Chen,Feng Wang

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