中山大学:人类肠道宏基因组数据库gutMEGA
  • 人肠道宏基因组图谱(gutMEGA)是一个注释良好的综合数据库,共保存了人类182项已发表研究的定量肠道菌群数据集;
  • 通过整理表型,肠道菌群组成及实验信息(样本来源,测序方法,处理软件等),gutMEGA整合了在776个条件中,7个分类水平下(界、门、纲、目、科、属、种)共6457个分类单元的59123个定量信息;
  • gutMEGA网站还具有多种浏览和搜索功能,可为用户提供一种快速简便的获取各表型间肠道菌群相对丰度的方法。
主编推荐语
刘永鑫-中科院-宏基因组
为了方便科学家查询和检索已发布的肠道菌群宏基因组测序数据,在这项研究中,中山大学第一附属医院的Xiaoxing Li和中山大学附属肿瘤医院的Ze-Xian Liu与团队,开发了肠道宏基因组图谱(gutMEGA),这是一个注释齐全的综合数据库,用于管理和托管来自人类已发表的肠道菌群定量数据集。通过仔细整理肠道菌群的组成,表型和实验信息,gutMEGA最终在776个条件下整合了7种不同水平(界,门,纲,目,科,属和种)的6457类群的59132个定量信息。此外,通过各种浏览和搜索功能,gutMEGA为用户提供了一种快速简便的方法来获取表型之间肠道微生物的相对丰度。总体而言,gutMEGA是用于肠道宏基因组研究的便捷而全面的资源,可以从 http://gutmega.omicsbio.info 免费访问。
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gutMEGA: a database of the human gut MEtaGenome Atlas

gutMEGA:人类肠道宏基因组图谱数据库

10.1093/bib/bbaa082

2020-06-04, Article

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The gut microbiota plays important roles in human health through regulating both physiological homeostasis and disease emergence. The accumulation of metagenomic sequencing studies enables us to better understand the temporal and spatial variations of the gut microbiota under different physiological and pathological conditions. However, it is inconvenient for scientists to query and retrieve published data; thus, a comprehensive resource for the quantitative gut metagenome is urgently needed. In this study, we developed gut MEtaGenome Atlas (gutMEGA), a well-annotated comprehensive database, to curate and host published quantitative gut microbiota datasets from Homo sapiens. By carefully curating the gut microbiota composition, phenotypes and experimental information, gutMEGA finally integrated 59 132 quantification events for 6457 taxa at seven different levels (kingdom, phylum, class, order, family, genus and species) under 776 conditions. Moreover, with various browsing and search functions, gutMEGA provides a fast and simple way for users to obtain the relative abundances of intestinal microbes among phenotypes. Overall, gutMEGA is a convenient and comprehensive resource for gut metagenome research, which can be freely accessed at http://gutmega.omicsbio.info.

First Authors:
Qingfeng Zhang,Kai Yu,Shihua Li

Correspondence Authors:
Ze-Xian Liu,Xiaoxing Li

All Authors:
Qingfeng Zhang,Kai Yu,Shihua Li,Xiaolong Zhang,Qi Zhao,Xia Zhao,Zekun Liu,Han Cheng,Ze-Xian Liu,Xiaoxing Li

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