清华大学程功:蚊子带不带“毒”,跟肠道菌有关
  • 用抗生素削减埃及伊蚊的肠道细菌,可减少虫媒病毒对蚊子的感染,从蚊子的21种肠道细菌中鉴定出粘质沙雷氏菌可增强蚊子对虫媒病毒的易感性;
  • 粘质沙雷氏菌分泌的蛋白SmEnhancin,可特异性降解伊蚊肠上皮表面的粘蛋白,从而破坏其肠道屏障,促进虫媒病毒的感染和扩散;
  • 携带粘质沙雷氏菌的野生伊蚊对登革病毒的易感性上升,给不带该菌的野生伊蚊定殖粘质沙雷氏菌,可增强其对虫媒病毒的易感性。
主编推荐语
mildbreeze
蚊子在吸血的同时可将人体携带的病毒一并吃进肚里,这些病毒突破蚊子的肠道屏障感染蚊子唾液腺,从而使蚊子成为病毒的传播者。清华大学程功团队本周在Cell Host and Microbe发表研究,发现蚊子肠道内的共生菌——粘质沙雷氏菌,可增强伊蚊对虫媒病毒的易感性,并揭示了背后的机制,为防控蚊媒病毒提供了新思路。人体肠道内可能也有类似的宿主-菌群-病毒互作机制,这些发现也为防治肠道病毒的感染和传播带来启示。
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A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses

一种肠道共生细菌促进蚊子对虫媒病毒的接受性

10.1016/j.chom.2018.11.004

2018-12-27, Article

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Mosquitoes are hematophagous vectors that can acquire human viruses in their intestinal tract. Here, we define a mosquito gut commensal bacterium that promotes permissiveness to arboviruses. Antibiotic depletion of gut bacteria impaired arboviral infection of a lab-adapted Aedes aegypti mosquito strain. Reconstitution of individual cultivable gut bacteria in antibiotic-treated mosquitoes identified Serratia marcescens as a commensal bacterium critical for efficient arboviral acquisition. S. marcescens facilitates arboviral infection through a secreted protein named SmEnhancin, which digests membrane-bound mucins on the mosquito gut epithelia, thereby enhancing viral dissemination. Field Aedes mosquitoes positive for S. marcescens were more permissive to dengue virus infection than those free of S. marcescens. Oral introduction of S. marcescens into field mosquitoes that lack this bacterium rendered these mosquitoes highly susceptible to arboviruses. This study defines a commensal-driven mechanism that contributes to vector competence, and extends our understanding of multipartite interactions among hosts, the gut microbiome, and viruses.

First Authors:
Pa Wu

Correspondence Authors:
Gong Cheng

All Authors:
Pa Wu,Peng Sun,Kaixiao Nie,Yibin Zhu,Mingyu Shi,Changguang Xiao,Han Liu,Qiyong Liu,Tongyan Zhao,Xiaoguang Chen,Hongning Zhou,Penghua Wang,Gong Cheng

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