国内团队:母乳中链氯化石蜡暴露需关注
创作:尹小甜 审核:Epi汪 04月02日
  • 在中国11个省份包括城市和农村地区采集母乳样本,分别检测短链氯化石蜡(SCCPs)和中链氯化石蜡(MCCPs)浓度;
  • 城市和农村地区SCCP中位浓度分别为393、525ng/g,而MCCP的中位浓度分别为472、567ng/g;
  • 2007至2017年间,城市地区的SCCP水平呈下降趋势,可能适合由于MCCP的广泛制造和应用;
  • 城市和农村地区通过母乳SCCP估计膳食摄入量分别为1230、2510ng/kg·d,而MCCP分别为2150、1890ng/kg·d;
  • 高含量的MCCP应引起公共卫生关注。
主编推荐语
Epi汪
来自中国科学院大学多个科研机构合作的调查研究显示,我国女性母乳中含有较高浓度的短链氯化石蜡和中链氯化石蜡;其中城市和农村地区的暴露情况差异较大。中链氯化石蜡是近年来使用较多的,可能对婴儿发育造成影响,需要引起关注。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Highly elevated levels, infant dietary exposure and health risks of medium-chain chlorinated paraffins in breast milk from China: Comparison with short-chain chlorinated paraffins

与短链氯化石蜡相比,中国母乳中中链氯化石蜡与婴儿膳食接触和健康风险的关联提高

10.1016/j.envpol.2021.116922

03-10, Article

Abstract & Authors:展开

Abstract:收起
Short-chain chlorinated paraffins (SCCPs) are persistent organic pollutants which are toxic to human. Median-chain chlorinated paraffins (MCCPs) have similar toxicity to SCCPs. The productions of chlorinated paraffins (CPs) in China were 1 million tons in 2013 and remained high after that, which may lead to high risks for human exposure to CPs. To investigate temporal trends and health risks of SCCPs and MCCPs in breast milk in China, samples (n = 2020) were collected from urban and rural areas of 11 Chinese provinces in 2017 and mixed into 42 pooled samples. SCCPs and MCCPs were analyzed by two-dimensional gas chromatography with electron-capture negative-ionization mass spectrometry (GC × GC-ECNI-MS). The MCCP concentrations (median (range)) were 472 (94–1714) and 567 (211–1089) ng g−1 lipid in urban and rural areas, respectively, which showed continuously rapidly increasing during 2007–2017. The SCCP concentrations (median (range)) were 393 (131–808) and 525 (139–1543) ng g−1 lipid in urban and rural areas, respectively. The results showed SCCP levels decreased in urban areas between 2007 and 2017. Significant increases in MCCP/SCCP ratios might arise from extensive manufacturing and use of MCCPs. The median estimated dietary intake via breast milk in urban and rural samples were 1230 and 2510 ng kg−1 d−1, respectively, for SCCPs and 2150 and 1890 ng kg−1 d−1, respectively, for MCCPs. Preliminarily risk assessment showed that SCCPs posed a significant health risk to infants via breastfeeding. The high MCCP levels should also be of concern because of continuous growth and negative effect on infants. Correspondence analysis indicated congeners with higher carbon and chlorine numbers in dietary tend to accumulate in breast milk.

First Authors:
Chi Xu

Correspondence Authors:
Lirong Gao

All Authors:
Chi Xu,Kunran Wang,Lirong Gao,Minghui Zheng,Jingguang Li,Lei Zhang,Yongning Wu,Lin Qiao,Di Huang,Shuang Wang,Da Li

评论