Metabolic dysfunction-associated fatty liver disease and subsequent development of adverse pregnancy outcomes
代谢功能障碍相关的脂肪肝和不良妊娠结局的后续发展
10.1016/j.cgh.2021.11.007
2021-11-16, Article
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Background & Aims: Recently, metabolic dysfunction-associated fatty liver disease (MAFLD), rather than nonalcoholic fatty liver disease (NAFLD), was proposed to better describe liver disease associated with metabolic dysfunction (MD). In this study, we attempted to investigate the impact of MAFLD on pregnancy complications.
Methods: The current study is a secondary analysis of a multicenter prospective cohort designed to examine the risk of NAFLD during pregnancy. In the first trimester, enrolled pregnant women were evaluated for hepatic steatosis by liver ultrasonography, and blood samples were collected for biochemical measurements. The study population was divided into three groups: no NAFLD, hepatic steatosis but without metabolic dysfunction (non-MD NAFLD), and MAFLD. The primary outcome was the subsequent development of adverse pregnancy outcomes, including gestational diabetes mellitus, pregnancy-associated hypertension, preterm birth, and fetal growth abnormalities.
Results: The study population consisted of 1,744 pregnant women, including 1,523 with no NAFLD, 43 with non-MD NAFLD, and 178 with MAFLD. The risk of subsequent development of adverse pregnancy outcomes was higher in MAFLD than in non-MD NAFLD (adjusted odds ratio, 4.03; 95% CI, 1.68-9.67), whereas the risk was not significantly different between no NAFLD and non-MD NAFLD. 3) Among women with no NAFLD, the presence of MD increased the risk of adverse pregnancy outcomes. However, women with MAFLD were at higher risk for adverse pregnancy outcomes than women with no NAFLD without MD or those with no NAFLD with MD.
Conclusions: In pregnant women, MAFLD may be associated with an increased risk of subsequent adverse pregnancy outcomes.
First Authors:
Seung Mi Lee
Correspondence Authors:
Won Kim,Joong Shin Park
All Authors:
Seung Mi Lee,Young Mi Jung,Eun Saem Choi,Soo Heon Kwak,Ja Nam Koo,Ig Hwan Oh,Byoung Jae Kim,Sun Min Kim,Sang Youn Kim,Gyoung Min Kim,Sae Kyung Joo,Bo Kyung Koo,Sue Shin,Errol R Norwitz,Chan-Wook Park,Jong Kwan Jun,Won Kim,Joong Shin Park
