营养摄入与人类健康衰老之间的多维关联
创作:一袋大侠 审核:章台柳 09月18日
  • 纳入1560 名老年人(>67岁)的生物衰老数据,整合血液生物标志物以量化衰老及生理平衡失调,并通过多维营养几何框架(GFN)建模技术探究营养摄入与衰老间的关系;
  • 营养素的最佳摄入水平视采用的衰老量化指标而定,且二者间的关系往往是非线性的;
  • 对于偏离标准一定范围内的营养摄入模式,生理平衡具有广泛的容忍度,即存在“稳态高原”;
  • 一种营养素的最佳摄入水平还取决于另一种营养素,单纯地增加或减少摄入可能弊大于利。
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章台柳
BMC Biology近期发表的文章,使用多维建模技术探究营养素摄入对老年人群生理性稳态失衡的影响,确定了特定营养素与最小生物老化相关的关键模式,或可为研究营养-衰老提供参考。
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BMC Biology [IF:7.364]

Multidimensional associations between nutrient intake and healthy ageing in humans

10.1186/s12915-022-01395-z

09-01, Article

Abstract & Authors:展开

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Background: Little is known about how normal variation in dietary patterns in humans affects the ageing process. To date, most analyses of the problem have used a unidimensional paradigm, being concerned with the effects of a single nutrient on a single outcome. Perhaps then, our ability to understand the problem has been complicated by the fact that both nutrition and the physiology of ageing are highly complex and multidimensional, involving a high number of functional interactions. Here we apply the multidimensional geometric framework for nutrition to data on biological ageing from 1560 older adults followed over four years to assess on a large-scale how nutrient intake associates with the ageing process.
Results: Ageing and age-related loss of homeostasis (physiological dysregulation) were quantified via the integration of blood biomarkers. The effects of diet were modelled using the geometric framework for nutrition, applied to macronutrients and 19 micronutrients/nutrient subclasses. We observed four broad patterns: (1) The optimal level of nutrient intake was dependent on the ageing metric used. Elevated protein intake improved/depressed some ageing parameters, whereas elevated carbohydrate levels improved/depressed others; (2) There were non-linearities where intermediate levels of nutrients performed well for many outcomes (i.e. arguing against a simple more/less is better perspective); (3) There is broad tolerance for nutrient intake patterns that don’t deviate too much from norms (‘homeostatic plateaus’). (4) Optimal levels of one nutrient often depend on levels of another (e.g. vitamin E and vitamin C). Simpler linear/univariate analytical approaches are insufficient to capture such associations. We present an interactive tool to explore the results in the high-dimensional nutritional space.
Conclusion: Using multidimensional modelling techniques to test the effects of nutrient intake on physiological dysregulation in an aged population, we identified key patterns of specific nutrients associated with minimal biological ageing. Our approach presents a roadmap for future studies to explore the full complexity of the nutrition-ageing landscape.

First Authors:
Alistair M Senior

Correspondence Authors:
Alistair M Senior

All Authors:
Alistair M Senior,Véronique Legault,Francis B Lavoie,Nancy Presse,Pierrette Gaudreau,Valérie Turcot,David Raubenheimer,David G Le Couteur,Stephen J Simpson,Alan A Cohen

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