不同的辅食引入方法,对婴儿肠道菌群的影响有差别
创作:mildbreeze 审核:mildbreeze
  • 分析改良的婴儿主导式断奶(BLISS,婴儿抓取手指食物自主进食)和传统方法(家长用勺子喂食糊状食物)添加辅食,对婴儿的食谱和粪便菌群组成的影响;
  • 与传统方法组相比,BLISS组婴儿在12月龄时肠道菌群α多样性和罗斯拜瑞氏菌属相对丰度均较低;
  • 科水平上,双歧杆菌、肠杆菌、韦荣球菌、拟杆菌、丹毒丝菌、毛螺菌和瘤胃球菌的相对丰度在两组间无显著差异;
  • 较低的果蔬和膳食纤维摄入是BLISS组菌群α多样性较低的部分原因。
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mildbreeze
引入辅食的方式可能影响婴儿的肠道菌群,Applied and Environmental Microbiology发表的一项最新研究,在74名婴儿中分析婴儿主导式断奶与传统断奶方法对婴儿肠道菌群组成的影响,并用中介分析方法鉴定出与此相关的饮食成分因素。
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Mediation analysis as a means of identifying dietary components that affect the fecal microbiota of infants weaned by modified baby-led, compared to traditional, approaches

用中介分析方法鉴定与传统断奶方法相比改良婴儿主导式断奶中影响婴儿粪便菌群的饮食成分

10.1128/AEM.00914-18

2018-07-13, Article

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The introduction of 'solids' (i.e. complementary foods) to the milk-only diet of early infancy affects the development of the gut microbiota. The aim of this study was to determine whether a 'baby-led' approach to complementary feeding, that encourages early introduction of an adult type diet, results in alterations to gut microbiota composition compared to traditional spoon-feeding. The Baby-Led Introduction to SolidS (BLISS) study randomized 206 infants to BLISS (a modified version of Baby-Led Weaning (BLW): introduction of solids at 6 months of age, followed by self-feeding of family foods) or Control (traditional spoon-feeding of purées) groups. Fecal microbiotas and 3-day weighed diet records were analysed from a subset of 74 infants at 7 and 12 months of age. The composition of the microbiota was determined by sequencing 16S rRNA genes amplified by PCR from bulk DNA extracted from feces. Diet records were used to estimate food and dietary fiber intake. Alpha diversity (number of Operational Taxonomic Units; OTUs) was significantly lower in BLISS infants at 12 months (difference, 95% CI: 31, 3.4 to 58.5; p = 0.028) and, while there were no significant differences between Control and BLISS infants in relative abundances of or at 7 or 12 months of age, OTUs representing the genus were less prevalent in BLISS microbiotas at 12 months. Mediation models demonstrated that 'fruit and vegetables' and 'dietary fiber' intake explained 29% and 25% respectively of the relationship between group (BLISS versus Control) and alpha diversity. The introduction of solid foods (complementary feeding, weaning) to infants leads to more complex compositions of microbial communities (microbiota, microbiome) in the gut. In Baby Led Weaning (BLW), infants are given only finger foods they can pick up and feed themselves - there is no parental spoon-feeding of puréed baby foods - and infants are encouraged to eat family meals. BLW is a new approach to infant feeding that is increasing in popularity in the United States, New Zealand, the United Kingdom and Canada. We used mediation modeling, commonly used in health research but not until now in microbiota studies, to identify particular dietary components that affected the development of the infant gut microbiota.

First Authors:
Claudia Leong

Correspondence Authors:
Gerald W Tannock

All Authors:
Claudia Leong,Jillian J Haszard,Blair Lawley,Anna Otal,Rachael W Taylor,Ewa A Szymlek-Gay,Elizabeth A Fleming,Lisa Daniels,Louise J Fangupo,Gerald W Tannock,Anne-Louise M Heath

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